补硒对预防原发性肝癌的作用  

Effect of Supplementing Selenium on Preventing Primary Liver Cancer

作　　者：李文广[1] 倪正平[1] 张启南[1] 于树玉[2] 诸亚君[2] 

机构地区：[1]江苏省启东肝癌防治研究所,启东226200 [2]中国医科院肿瘤研究所

出　　处：《广东微量元素科学》1997年第7期25-30,共6页Trace Elements Science

摘　　要：原发性肝癌病因为多因素协同作用的结果，我国肝癌病因以乙型肝类病毒（HBV）、黄曲霉毒素B1（AFB1巳）、饮水污染和遗传等因素为主。某些微量元素缺乏，促进了肝癌的发生、发展。科学工作者针对肝癌病因采取以“防治肝炎、管粮防霉、改良饮水、适量补硒”为中心的综合防治措施，已取得初步成效，本研究进一步阐明在肝癌高发现场应用补硒预防肝癌的作用。通过四年前瞻研究结果表明，食硒盐补硒组较对照组血硒GSH－px升高，UDS、微核出现率减少．对乙型肝炎病毒感染率（HBsAg）下降，肝癌发病率有下降。趋势。两组肝肾功能阳性率无明显差异。提示在肝癌高发区，尤其是低硒地区适量补硒可以降低肝癌发病率。Primary liver cancer results from mult-factor cooperation. It is mostly cauesd by HBV,AFB1, drinking-water pollution and heredity. Deficiency of some trace elements can promote its genesis and development. Scientists adopted a series of synthetic steps of 'preventing and curing hepatitis, controlling grains aganist funguses, improving drinking-water, supplementing selenium properly', and have gained preliminary success. This study further reports the value of supplementing selenium in hepatocarcinoma preventing in the high incidence area. A four year prospective study shows that those administrated Se-salt had a higher level of sele nium and GSH-px in the boold,whi1e UDS and micronucleus rate, HBV infection and hepatocarcinoma morbidity tended to reduce compared with the control. Hepato-renal functions of these two groups had no significant difference. It suggested that selenium-complement can reduce the hepatocarcinoma morbidity in the high incidence area, especially in the regions of low selenium.

关 键 词：硒 原发性肝癌 预防 肝癌 

分 类 号：R735.701[医药卫生—肿瘤]