3-芳基-5-巯基-1,2,4-均三唑的双-Mannich反应研究  

Studies on Double Mannich Reaction of 3-Aryl-5-mercapto-1, 2, 4-triazoles

作　　者：王忠义[1] 尤田耙[1] 史海健[2] 史好新[2] 

机构地区：[1]中国科技大学化学物理系,合肥230026 [2]安徽师范大学化学系,芜湖241000

出　　处：《高等学校化学学报》1997年第4期550-553,共4页Chemical Journal of Chinese Universities

基　　金：安徽省教育委员会和科学技术委员会自然科学基金

摘　　要：研究了在氯化氢-乙醇溶液中，3-芳基-5-巯基-1，2，4-均三唑与甲醛和伯胺（芳胺或脂肪胺）的双Mannich反应，合成了13种新的稠杂环化合物3，5-二取代-四氢均三唑并[3，4-b][1，3，5]噻二嗪.经元素分析、IR、1HNMR和MS确定了产物的结构，初步测定了该类化合物的生物活性．In this paper, thirteen new 3, 5-disubstltuted tetrahydro-s-triazolo [3' 4-b][1' 3,5]thiadiazines were prepared by double Mannich reaction in the presence of HCl-ethanol so-lution, arylamine-HCl and 37% aqueous formaldehyde solution or the condensation productof arylamine and para formaldehyde were reacted with 3-aryl-5-mercapto-1, 2, 4-triazole toform the title compounds at 45~65℃.The structure of these compounds were characterizedby elementary analysis, IR, 1H NMR and MS.Their antibactericidal activity against E. Col-i, B- Subtilis and S. Aureus were tested.

关 键 词：生物活性 均三唑 MANNICH碱 噻二嗪 

分 类 号：O626[理学—有机化学] R978[理学—化学]