吸烟对PHC手术后复发患者血清AFP和VEGF水平的影响  

Effect of Smoking on the Serum AFP and VEGF of the Patients with Primary Hepatic Carcinoma After the Radical Excision

作　　者：唐斌[1] 林源[2] 

机构地区：[1]湖南省怀化市第一人民医院肝胆外科,湖南怀化418000 [2]中南大学湘雅医院中西医结合研究所,湖南长沙410008

出　　处：《医学临床研究》2008年第1期19-20,共2页Journal of Clinical Research

基　　金：湖南省自然科学基金重点项目(No.06JJ20050)

摘　　要：【目的】观察吸烟对原发性肝癌(PHC)行根治性切除后复发患者血清甲胎蛋白(AFP)、血管内皮细胞生长因子(VEGF)水平的影响。【方法】将入选的46例PHC手术后复发患者分为吸烟组(n=20)和对照组(n=26),并与20例正常人比较,用放射免疫方法与酶联免疫吸附法(ELISA)分别测定血清AFP、VEGF水平。【结果】复发患者血清AFP与VEGF水平均高于正常人(P<0.01);吸烟组血清VEGF水平高于对照组与正常组(P<0.01);吸烟组血清AFP水平与对照组相当。【结论】吸烟可能通过提高肝癌手术患者血清VEGF水平,促进术后复发。[Objective]To study the effects of smoking on the serum AFP and VEGF of the patients with primary hepatic carcinoma after the radical excision. [Methods]According to the factor of smoking, 46 patients selected were divided into two groups： smoking group（ n ： 20）and control group（ n = 26）, and compared with normal group （ n =20）. All groups had been undergone the detection of serum AFP and VEGF using radioimmunity and ELISA respectively. [Results]The serum AFP and VEGF of the patients selected were higher than those of the healthy （ P 〈0. 01）. The serum VEGF in smoking group was markedly increased in contrast to control group and normal group （ P 〈0. 01）, but the serum AFP similar to control group. [Conclusion]Smoking may promote the relapse of primary hepatic carcinoma after the radical excision by elevating the serum VEGF.

关 键 词：肝肿瘤/外科学 肿瘤复发 局部 吸烟 甲胎蛋白类/血液 内皮生长因子/血液 

分 类 号：R735.7[医药卫生—肿瘤]