WWOX抑癌基因研究进展  

Update of the WWOX tumor suppressor gene

作　　者：杨吉龙[1] 杜晓玲[2] 张微 朱雄增[4] 

机构地区：[1]天津医科大学附属肿瘤医院骨与软组织肿瘤科,天津300060 [2]天津医科大学基础医学院诊断学教研室,天津300070 [3]Department of Pathology,the University of Texas M.D.Anderson Cancer Center.1515Holcombe Blvd.Houston.Texas 77030 [4]复旦大学附属肿瘤医院病理科,上海200032

出　　处：《中国癌症杂志》2008年第1期68-72,共5页China Oncology

摘　　要：WWOX基因定位于染色体16q23.3-24.1,在卵巢癌、乳腺癌、肝细胞癌、前列腺癌及其他肿瘤中检测到其杂合性缺失及染色体重排。该基因位于染色体普通脆性位点16D,包含9个外显子,编码414个氨基酸相对分子量为46000大小的蛋白。原发肿瘤组织及细胞系的研究证明该基因为肿瘤抑制基因,其失活可能导致肿瘤的发生,基因敲除实验证实了上述假设。WWOX可能和c-Jun,TNF,p53,p73,AP-2γ,及E2F-1等相互作用而发挥凋亡作用。目前对于该基因是否为肿瘤抑制基因仍存在不同观点,随着研究结果的积累,WWOX基因的功能会日渐明了,并对肿瘤的诊断、治疗和预防产生积极的影响。The WWOX gene, which is located at 16q23.3-24. 1., Its deletion of heterozygosis and chromosomal rearrangements has been detected in ovarian, breast, hepatocellular, and prostate carcinomas and in other neoplasias. This gene, which spans the common chromosomal fragile site 16D, contains 9 exons and encodes a 46 000 WWOX protein that contains 414 amino acids. The evidence from cancer cell lines and primary tumor tissues suggests that WWOX is a tumor suppressor gene and that its inactivation contributes to cancer development. The results from studies of WWOX gene knock- out cancer cells and a WWOX knockout mouse model partly confirm this hypothesis. The WWOX protein can interact with c-Jun, TNF, p53, p73, AP-2gamma and E2F-1, and plays a central role in tumor apoptosis. However, it is still controversial whether WWOX is a tumor suppressor gene. As the researches carry on, the function of WWOX will be unveiled, and the gene may play an active role in prevention, diagnosis and the treatment of tumor.

关 键 词：WWOX基因 肿瘤抑制基因 凋亡 

分 类 号：R730.231[医药卫生—肿瘤]