Variations of dendritic cell-specific intercellualar adhesion molecule-3-grabing nonintegrin neck region in HIV infected individuals  

作　　者：XU Li-jun YAO Hang-ping LI Dan WANG Zhi-gang CHEN Liang WU Nan-ping 

机构地区：[1]Institute of Infectious Diseases, First Affiliated Hospital ofZhejiang University, Hangzhou, Zhejiang 310003, China [2]Shanghai Public Health Clinical Center, Shanghai 201508, China [3]Zhejiang Center for Disease Prevention and Control, Hangzhou,Zhejiang 310004, China [4]Department of Infectious Diseases, Jishuitan Hospital, Beijing100035, China

出　　处：《Chinese Medical Journal》2008年第3期265-267,共3页中华医学杂志（英文版）

基　　金：This study was supported by a grant from the National Natural Science Foundation of China （No. 30471538）.

摘　　要：Dendritic cells （DCs） play a critical role in initiating the immune response by virtue of their ability tocapture and present antigens to T ceils.^1 Although the precise mechanism by which DCs acquire human immunodeficiency virus （HIV-1） is not completely understood, migration of DCs from the periphery to the draining lymph nodes may enable CD4^＋ T cells to become infected.^2 DC-specific intercellular adhesion molecule 3 grabbing nonintegrin （DC-SIGN, CD209）, a mannose specific C-type lectin receptor on DCs, plays a vital role in this process by binding HIV-gp120 and helping DCs transport HIV from the infection site to the secondary lymph nodes.^3 DC-SIGN related lectin （DC-SIGNR, or L-SIGN, CD209R） shares 77% amino acid identity with DC-SIGN, and is expressed on endothelial cells in the liver, lymph nodes and placental capillaries.^4 Both DC-SIGN and DC-SIGNR are HIV receptors .5Dendritic cells （DCs） play a critical role in initiating the immune response by virtue of their ability tocapture and present antigens to T ceils.^1 Although the precise mechanism by which DCs acquire human immunodeficiency virus （HIV-1） is not completely understood, migration of DCs from the periphery to the draining lymph nodes may enable CD4^＋ T cells to become infected.^2 DC-specific intercellular adhesion molecule 3 grabbing nonintegrin （DC-SIGN, CD209）, a mannose specific C-type lectin receptor on DCs, plays a vital role in this process by binding HIV-gp120 and helping DCs transport HIV from the infection site to the secondary lymph nodes.^3 DC-SIGN related lectin （DC-SIGNR, or L-SIGN, CD209R） shares 77% amino acid identity with DC-SIGN, and is expressed on endothelial cells in the liver, lymph nodes and placental capillaries.^4 Both DC-SIGN and DC-SIGNR are HIV receptors .5

关 键 词：dendritic cells specific intercellualar adhesion molecule-3-grabing nonintegrin HIV SUSCEPTIBILITY 

分 类 号：R512.91[医药卫生—内科学]