间歇性雄激素阻断治疗对晚期前列腺癌患者生活质量的影响  

The Impact of Intermittent Androgen Blockade on the Quality of Life for Patients with Advanced Prostate Cancer

作　　者：陈伟[1] 邓哲宪[1] 余志贤[1] 张方毅[1] 陈盛烨[1] 李叶平[1] 吴秀玲[2] 翁志梁[1] 

机构地区：[1]温州医学院附属第一医院泌尿外科,浙江省温州市325000 [2]温州医学院附属第一医院病理科,浙江省温州市325000

出　　处：《中国肿瘤临床》2008年第3期124-127,共4页Chinese Journal of Clinical Oncology

摘　　要：目的:调查间歇性雄激素阻断治疗(Intermittent Androgen Blockade,IAB)对晚期前列腺癌患者生活质量的影响。方法:采用EORTCQLQ-C30总量表和QLQ-PR25子量表对51例接受IAB治疗的晚期前列腺癌患者,分别在治疗前、治疗后6个月和治疗后12个月进行3次生活质量调查。结果:尽管IAB使家庭经济负担加重(P<0.05),但在间歇期负担减轻(P<0.05)。IAB治疗6个月后患者总体健康状况明显好转(P<0.01),尤其在治疗间歇期更加明显(P<0.05);全身或局部疼痛缓解(P<0.01);排尿症状改善(P<0.01);虽然治疗6个月时患者躯体(P<0.05)、角色(P<0.05)、情绪(P<0.01)、社会(P<0.01)等功能均有不同程度下降,且疲倦加剧(P<0.01),但在12个月进入间歇期后这些功能逐渐恢复。治疗相关症状如潮红与乳房胀痛等在6个月时显著出现(P<0.01),但12个月时减轻(P<0.01)。治疗期性趣明显下降(P<0.01)、性生活丧失,但在间歇期有不同程度的恢复(P<0.01)。结论:虽然IAB对晚期前列腺癌患者的机体与心理有不同程度的影响,但其是可恢复的。Objective： To investigate the quality of life of patients with advanced prostate cancer after treatment with intermittent androgen blockade（IAB）. Methods： A total of 51 patients with advanced prostate cancer treated with IAB underwent the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire （QLQ-C30） and the QLQ-prostate specific 25-item module （PR25）. The assessment was made 3 times： once before treatment, once 6 months after treatment and once 12 months after treatment. Results： In spite of the increased financial burden, IAB benefited patients. At 6 and 12 months after treatment, improvement was observed in pain relief, urinary symptoms and global health （P〈0.01）. Six months after treatment, patients treated with IAB presented with decreased physical, role, emotional and social functions compared to those same patients before treatment（P〈0.01）. At that time patients also had symptoms related to the treatment itself including flushed skin, breast pain and decreased libido. The above functions were improved and the treatment-related symptoms were relieved by the 12th month after treatment. Conclusion： IAB can effectively improve the quality of life for patients with advanced prostate cancer, It temporarily impairs physical and psychological functions, but these functions can be fully recovered within 12 months of treatment.

关 键 词：晚期前列腺癌 间歇性雄激素阻断治疗 生活质量 

分 类 号：R737.25[医药卫生—肿瘤]