氯氮平、利培酮、奥氮平、喹硫平和氟哌啶醇对首发精神分裂症患者血浆瘦素的影响  

Effects of ciozapine, risperidone, olanzapine, quetiapine and haloperidoi on plasma ieptin in first-episode schizophrenic patients

作　　者：汪卫华[1] 赵汉清[1] 王焕林[1] 汪广剑[1] 崔庶[1] 宋梓祥[1] 闫同军[1] 仲爱芳[1] 薛蕴庄 

机构地区：[1]解放军第102医院,常州213003

出　　处：《中国行为医学科学》2008年第2期138-140,共3页Chinese Journal of Behavioral Medical Science

摘　　要：目的探讨氯氮平、利培酮、奥氮平、喹硫平和氟哌啶醇对首发精神分裂症患者血浆瘦素水平的影响。方法首发精神分裂症患者114例随机分为5组，分别是氯氮平组（33例）、利培酮组（31例）、奥氮平组（30例）、喹硫平组（30例）和氟哌啶醇组（30例），分别给予相应的药物治疗，治疗前和治疗后第6周末用放射免疫法测定血浆瘦素含量，并测量身高、体质量，计算体质量指数（BMI）。结果①治疗后氯氮平组、利培酮组、奥氮平组、喹硫平组血浆瘦素含量[分别为（12．88±3．12）μg/L、（11．84±4．26）μg/L、（11．52±3．44）μg/L、（11．38±2．92）μg/L]比治疗前明显升高（P〈0．01，P〈0．05）；氟哌啶醇组、氯氮平组、利培酮组、奥氮平组、喹硫平组治疗前后瘦素变化分别为（0．23±1．42）μg/L、（3．88±2．12）μg/L、（2．12±1．95）μg/L、（2．82±2．40）μg/L、（1．68±1．92）μg/L，其中氯氮平组和奥氮平组、氟哌啶醇组之间差异有显著性（P〈0．05）；②治疗后氯氮平组、利培酮组、奥氮平组、喹硫平组体质量[分别为（25．40±3．41）kg／m^2、（25．27±4．03）kg／m^2、（25．93±4．72）kg／m^2、（24．99±2．97）kg／m^2]比治疗前[分别为（23．11±3．45）kg／m^2、（24．47±2．97）kg／m^2、（23．88±3．09）kg／m^2、（24．31±3．29）kg／m^2]明显升高（P〈0．01，P〈0．05）。氟哌啶醇组、氯氮平组、利培酮组、奥氮平组、喹硫平组治疗前后体质量变化分别为（0．31±1．22）kg／m^2、（2．37±2．11）kg/m^2、（1．32±1．77）kg/m^2、（2．07±1．38）kg/m^2、（1．17±1．72）kg／m^2，氯氮平组、奥氮平组分别与利培酮组、喹硫平组、氟哌啶醇组之间均差异具有显著性（均P〈0．05），而利培酮组、喹硫平组之间、氯氮平与奥氮平组之间差异无显著性（均P〉0．05）。③氯氮平组、Objective To explore the effects of clozapine, risperidone, olanzapine, quetiapine and haloperidol on plasma leptin in first-episode schizophrenic patients. Methods 114 first episode schizophrenics were randomly divided into five groups, which were treated with clozapine, olanzapine, quetiapine,risperidone and haloperidol, respectively. The plasma leptin concentration was measured with radioimmunoassay pre-treatment and 6 weeks post-treatment. Results （1） Plasma leptin level of post-treatment [ （ 12. 88 ± 3. 12 ） μg/L, （ 11.84 ± 4.26） μg/L, （ 11.52 ±3.44） μg/L, （ 11.38 ±2.92 ） μg/L] increased compared with that of pre-treatment in both clozapine group （ P 〈 0.01 ）, risperidone group （ P 〈 0.05 ）, olanzapine group （ P 〈 0.05 ） and quetiapine group （ P 〈 0.05 ）, and significant difference of the increased value of plasma leptin was found after treatment between cloza- pine, olanzapine and haloperidol groups （ P 〈 0.05 ）. （2） Body mass [ （ 25.40 ± 3.41 ） kg/m^2, （ 25.27 ± 4.03 ） kg/m^2, （25.93 ± 4.72） kg/m^2, （24.99 ± 2.97） kg/m^2 ] after treatment increased compared with that before treatment [（23.11 ±3.45）kg/m^2 ,（24.47±2.97）kg/m^2 ,（23.88 ±3.09）kg/m^2,（24.31 ±3.29）kg/m^2] in clozapine group（ P 〈 0.01 ）, risperidone group （ P 〈 0.05 ）, olanzapine group （ P 〈 0.01 ） and quetiapine group （ P 〈 0. 05）, and significant difference of the body mass gain was found between clozapine, olanzapine group, risperidone, quetiapine group, and haloperidol groups respectively （ P 〈 0.05）. （3） The increased values of plasma leptin at the 6th weekend were positively correlated to the body mass gain in clozapine group（ r= 0.714, P〈 0.01 ）, risperidone group（ r= 0. 625, P〈 0.01 ）, olanzapine group （ r= 0. 594, P〈 0.01 ） and quetiapine group（ r= 0.735, P 〈 0.01 ）. Conclusion Clozapine, risperidone, olanzapine and quetiapine have significant effects on plasma leptin concentration

关 键 词：氯氮平 维思通 奥氮平 喹硫平 氟哌啶醇 精神分裂症 瘦素 

分 类 号：R749.3[医药卫生—神经病学与精神病学]