Evaluating effects of gypenosides and soyasaponins on differentiation of neural stem cells as an in vitro model  

作　　者：吴婕 文铁桥 

机构地区：[1]Laboratory of Neural Molecular Biology, School of Life Sciences, Shanghai University, Shanghai 200444, P. R. China

出　　处：《Journal of Shanghai University(English Edition)》2008年第1期91-94,共4页上海大学学报（英文版）

基　　金：Project supported by the National Basic Research Program of China （Grant No.2006CB500702）, the National Natural Science Foundation of China （Grant No.30570590）, and the Science Foundation of Shanghai Municipal Commission of Science and Technology （Grant No.03JC14030）

摘　　要：Neural stem cell has a potential to differentiate into neurons, astrocytes and oligodendrocytes. It provides an in vitro model to screen herbal medicines on the cellular differentiation and development level. In this work, active component from gypenosides and soyasaponins was prepared to investigate their effects on the differentiation of neural stem cells.. Both gypenosides and soyasaponins promote the differentiation of neural stem cells. This method provides speed and practicality for screening effective herbal medicine. It is well suited for studying the mechanism of cell differentiation and development.Neural stem cell has a potential to differentiate into neurons, astrocytes and oligodendrocytes. It provides an in vitro model to screen herbal medicines on the cellular differentiation and development level. In this work, active component from gypenosides and soyasaponins was prepared to investigate their effects on the differentiation of neural stem cells.. Both gypenosides and soyasaponins promote the differentiation of neural stem cells. This method provides speed and practicality for screening effective herbal medicine. It is well suited for studying the mechanism of cell differentiation and development.

关 键 词：neural stem cell GYPENOSIDES SOYASAPONINS herbal medicine in vitro model 

分 类 号：Q2[生物学—细胞生物学]