脑血栓与血小板活化关系的研究  

Investigation of the relation between cerebral thrombosis and platelet activated

作　　者：刘彦虹[1] 安晶红[1] 

机构地区：[1]黑龙江中医药大学博士后科研流动站,黑龙江哈尔滨150040

出　　处：《中国实验诊断学》2008年第2期220-221,共2页Chinese Journal of Laboratory Diagnosis

基　　金：黑龙江省科技厅攻关项目(GB06C40303)

摘　　要：目的探讨脑血栓患者血小板活化状态。方法采用全血流式细胞术(FCM)三色荧光分析技术对100例脑血栓患者和100例健康人的血小板活化标志物CD62P,GPⅡb/Ⅲa(PAC-1)进行检测。结果脑血栓组血小板CD62P(12.97±2.86)%与PAC-1(25.31±2.61)%阳性百分率显著高于对照组[(5.48±2.37%,(14.82±1.88)%],两组间比较差异具有显著性(P<0.05)。结论脑血栓患者存在血小板活化,全血流式细胞术检测血小板活化可用于脑血栓的预防、治疗和复发监测。Objeetive To explore platelet activated sate in the patients with cerebral thrombosis.Methods The platelet activation markers CD62P,GPⅡ b/Ⅲ a（PAC-1） of 100 cerebral thrombosis patients and were100 healthy people were detected by flow cytometry （FCM） triad colour fluorimetric analysis technique. Results masculine percentage of platelet CD62P（ 12.97 ± 2.86） % and PAC- 1 （ 25.31 ± 2.61 ） % in the cexebral thrombosis were significantly higher than those of normal control[ （ 5.48 ± 2.37 ） %, （ 14.82 ± 1.88） % ],The difference between two sets was significance （ P 〈 0. 05 ）. Conclusion Platelet activation appears in the blood of cerebral thrombosis patients, The application of whole blood flow cytometric assay in detection of platelet activation might monitor the precaution, treatment and recurrent of cerebral thrombosis.

关 键 词：脑血栓 血小板活化 流式细胞术 

分 类 号：R743[医药卫生—神经病学与精神病学]