妊娠中期检测血AFP和游离绒毛膜促性腺激素对唐氏综合征筛查的临床研究  

The study of detecting the AFP and Free-β-HCG blood level at mid trimester of pregnancy for screening the Down's syndrom

作　　者：邱锦[1] 李明勋[1] 朴锦丹[1] 

机构地区：[1]大庆油田总医院妇产科,黑龙江大庆163001

出　　处：《中国实验诊断学》2008年第2期240-242,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的对妊娠中期孕母血清生化标志物筛查唐氏综合征进行临床研究。方法对我院8350例妊娠14-20周孕妇进行血清甲胎蛋白(AFP)和游离绒毛膜促性腺激素(free--βHCG值)检测,切割值为1∶300,对高风险者行羊水检查。结果唐氏综合征高风险396例,筛查阳性率4.74%,其中异常5例。唐氏综合征高风险组胎儿异常的发生率高于唐低综合征低风险组(P<0.05)。≥35岁组孕妇唐氏综合征高风险率大于<35岁组(P<0.05)。结论AFP及free--βHCG值可用于妊娠14-20周孕妇筛查唐氏综合征。Objective To study the biochemical criterion of mid trimester of pregnancy for screening Down＇ s syndrome. Methods To detecting the blood level of AFP and free-β-HCG of 8350 pregnancy women between 14 - 20 weeks of our hospital. Cutting numerical value is 1 ： 300. Did the amniotic fluid examination for high risk women. Results The pregnancy women with high risk are 396 patients. The active screening rate is 4.74%, including 5 women with Down＇ s syndrome fetus. In the group of pregnancy women with high risks of Down＇s syndrome,the unwonted fetus originating rate is higher than the lower risks women （ P 〈 0.05）. The pregnancy women＇ s age is equal or older than 35ys old has high risk of Down＇ s syndrome than younger women. （ P 〈 0.05）. Conclusion AFP and free-β-HCG can be used to screening Down＇ s syndrome between 14 - 20 weeks of pregnancy women.

关 键 词：唐氏综合征 产前筛查 

分 类 号：R714.2[医药卫生—妇产科学]