抑癌基因DPC4在结肠癌蛋白的表达及临床意义  被引量:3

Expression and Significance of DPC4 in colon Cancer

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作  者:谢忠士[1] 宋燕[1] 刘志毅[1] 武鸿斌[1] 赵航[1] 柳福海[1] 

机构地区:[1]吉林大学中日联谊医院肛肠外科,吉林长春130031

出  处:《中国实验诊断学》2008年第2期245-246,共2页Chinese Journal of Laboratory Diagnosis

摘  要:目的研究DPC4(Smad4)蛋白在结肠癌的表达及临床意义。方法应用免疫组化SP法,对80例结肠癌及28例癌周粘膜进行检测,并结合临床资料进行研究。结果结肠癌DPC4(Smad4)蛋白的表达阳性率为75%(60/80),28例癌周粘膜内DPC4(Smad4)蛋白均呈强阳性表达,两者比较差异有显著性意义(P<0.05)。DPC4蛋白在结肠癌的表达与患者年龄、发生部位无关(P>0.05),而与临床分期有关性(P<0.05)。结论DPC4(Smad4)蛋白的表达与结肠癌的发生发展密切相关,对预后的判断有参考价值。Objective To investigate the expression of DPC4 in colon cancer and evaluate its clinical significance, Methods DPC4 was measured in 80 cases of colon cancer tissues and 28 cases of benign disease by immunohistochemistry SP method using monoclonal antibody to their protein, Results The expression of DPC4 in colon cancer was 75 % (60/80). There was significantly higher than that in benign disease, Their expression was related to pathology stage clinical stage ( P 〈 0.05), Conclusion The expression of DPC4 was closely correlated with the colon cancer and more valuable about predicting

关 键 词:结肠癌 DPC4基因 免疫组化 

分 类 号:R735.35[医药卫生—肿瘤]

 

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