超早期溶栓联合围术期护脑药物治疗进展性脑梗死(附423例报告)  

Study of progressive cerebral infarction on super-earlier thrombolysis and cerebral protection

作　　者：宁学军 宁海春 

机构地区：[1]邢台市第三医院,河北邢台054000

出　　处：《山东医药》2008年第2期18-20,共3页Shandong Medical Journal

基　　金：河北省科学技术厅立项课题(00276154D)

摘　　要：目的观察超早期（首次病情进展至溶栓时间≤3h）溶栓联合围术期护脑药物治疗进展性脑梗死（PCI）的疗效与安全性。方法将846例PCI患者随机分为观察组和对照组各423例，两组均予抗炎、钙离子拮抗剂、减轻脑水肿、调治血压药、降糖药等常规及对症治疗，采用尿激酶超早期溶栓抗凝联合围术期应用护脑药物（黄芪注射液30ml＋葛根素注射液15ml＋复方丹参注射液20ml静滴）治疗；对照组仅行早期（首次病情进展至溶栓时间3—6h）溶栓治疗及抗凝治疗，方法同上。结果观察组总有效率显著高于对照组，并发症发生率显著低于对照组，P均〈0．01。结论超早期溶栓联合围术期应护脑药物治疗PCI能有效防治脑缺血和再灌注后脑损伤，且较为安全。Objective To observe the efficacy and the safety on cerebroproteetant region before and after ultra-earlier thrombolysis in treating progressive cerebral infarction. Methods 846 patients with progressive cerebral infarction were randomly divided into study group and control group. Among the patients in study group, within 3 hours after the first onset, cerebroprotectant region was applied. Among the patients in the control group, within 3-6 hours after the first onset, cerebroprotectant region was not applied before and after thrombolysis. Intraarterial thrombolysis or intravenous thrombolysis and anticoagulation were used in two groups. The routine treatment was same in two groups. The neural function defects were evaluated in the 10th day and 30th day, the living condition were also evaluated in the sixth month. Results The cure rate, the total effective rate and the improvement of nerve dysfunction and the safety in the study group were significant improved than that in the control group （P 〈 0.01 ）. Conclusion This methods can markedly increase the cure rate, reduce the death rate and complications, improve the living quality.

关 键 词：进展性脑梗死 超早期溶栓 护脑 疗效 

分 类 号：R743.33[医药卫生—神经病学与精神病学]