提高大鼠心肌梗死模型成功率及存活率的研究  

Methods on enhancing success rate and survival rate of rat model of myocardial infarction

作　　者：向平[1] 宋银子[2] 陈沅[1] 涂柳[3] 朱高慧[1] 

机构地区：[1]重庆医科大学儿童医院心血管内科,重庆400014 [2]香港中文大学儿科系,中国香港 [3]重庆医科大学基础医学院生理学教研室,重庆400016

出　　处：《第三军医大学学报》2008年第4期329-332,共4页Journal of Third Military Medical University

摘　　要：目的探讨结扎位置、冠状静脉变异等因素对大鼠心肌梗死(myocardial infarction,MI)模型建立的成功率以及利多卡因的使用对模型的死亡率的影响。方法120只雄性SD大鼠按随机排列表法分为4组:低位结扎且冠状静脉不明显组(30只)、低位结扎且冠状静脉明显组(30只)、高位结扎组(30只)以及高位结扎且使用利多卡因组(30只),计算建模后各组死亡率,测定各组心功能及梗死面积。结果结扎位置较高时模型成功率为93.0%,而结扎位置较低时的成功率为67.3%;高位结扎不加利多卡因大鼠死亡率为43.3%,加用利多卡因后大鼠死亡率则降为13.3%。结论高位结扎时能明显提高模型成功率,加用利多卡因后死亡率明显下降。Objective To investigate the effects of different ligation position, vena coronaria variation and lidocaine on myocardial infarction size and mortality in rats. Methods Totally 120 male SD rats were divided into four groups with 30 rats in each group： low ligation with invisible vena coronaria, low ligation with visible vena coronaria, high ligation, and high ligation plus lidocaine. Results MI was successfully created in 93.0% rats of high ligation groups and in 67.3% rats of low ligation groups. The mortality was 43.3% in rats of high ligation groups, only 13.3% in rats when lidocaine in use. Conclusion High ligation increases the success rate of rat model of myocardial infarction and the application of lidocaine decreases the mortality of the rat model.

关 键 词：冠脉结扎 心肌梗死 利多卡因 成功率 

分 类 号：R-332[医药卫生] R542.22