抗精神病药治疗与体质量和血脂等的关系  

Relationship among antipsychotic therapy and body weight and blood lipid etc

作　　者：汪卫华[1] 赵汉清[1] 王焕林[1] 汪广剑[1] 崔庶[1] 宋梓祥[1] 闫同军[1] 仲爱芳[2] 薛蕴庄 

机构地区：[1]解放军第102医院精神科,常州213003 [2]解放军第102医院化验科,常州213003

出　　处：《临床精神医学杂志》2008年第1期21-22,共2页Journal of Clinical Psychiatry

摘　　要：目的:探讨引起住院精神分裂症患者体质量增加的相关因素。方法:首发住院精神分裂症患者72例分别于治疗前和治疗6周末测定体质量、血清瘦素、胰岛素、胰岛素抗体、糖化血红蛋白(HbA1C)、空腹血糖、血清胆固醇(T-CHO)及三酰甘油(TG)。结果:服抗精神病药后体质量有显著性增高(t=7.865,P=0.000)。体质量变化与服药种类(γ=-0.400,P<0.01)等有关。结论:影响住院精神分裂症患者体质量变化最主要的3个因素为:服用精神药物种类、初始三酰甘油及瘦素变化量。Objective：To investigate the related factors contributing to weight gain of inpatients with schizophrenia. Method：72 inpatients with first-episode schizophrenia were recruited, examining body weight, serum leptin, insulin, insulin antibody, glycosylated hemoglobin （HbAtc ）, fasting plasma glucose, total cholesterol （T-CHO） and triglyceride （TG） before treatment and after 6 weeks of treatment respectively. Results： Compared with that before treatment, the body weight of post-treatment was significantly increased （t = 7. 865, P = 0.000）. The body mass gain was correlated with the kinds of antipsychotic drugs （y = - 0. 400, P 〈 0.01 ）, etc. Conclusion： The major factors that influence the inpatients＇ weight gain were the kinds of antipsychotic drugs, TG of prior to treatment and the change of leptin level.

关 键 词：抗精神病药 体质量 精神分裂症 瘦素 胰岛素 

分 类 号：R749.053[医药卫生—神经病学与精神病学]