舍曲林治疗老年抑郁症随访观察  

A follow-up observation of sertraline in treatment of senile patients with depression.

作　　者：张玉琦[1] 李桂林[1] 刘朝军[2] 刘庆海[2] 王爱荣[2] 

机构地区：[1]南京医科大学附属无锡精神卫生中心,无锡214151 [2]山东省安康医院

出　　处：《临床精神医学杂志》2008年第1期59-60,共2页Journal of Clinical Psychiatry

摘　　要：目的:探讨舍曲林治疗老年抑郁症的长期依从性、复发率。方法:258例患者分别服用舍曲林(132例)和阿米替林(126例),进行开放式对照研究,采用门诊、电话、信件等方法,分别于用药6、l2、24、36个月对患者随访,观察长期服药依从性及复发率。结果:舍曲林组的服药依从性显著较阿米替林组为佳,复发率显著较阿米替林组为低,不良反应少且轻微。结论:舍曲林可作为老年抑郁症的维持治疗药物。Objective：To investigate the compliance and relapse rate of senile depressive patients treated with sertraline. Method：A total of 258 senile depressive patients were assigned to take sertraline （ n = 132） or amitfiptyline （ n = 126）. The compliance and reapse rate were observed in the 6th, 12th, 24th, 36th months by consultant, telephone or letter. Results： The compliance of sertraline group was significantly better than that of amitriptyline group. The relapse rate was significantly lower in sertraline than in amitriptyline . The side effects were fewer in sertraline group. Conclusion： Sertraline may be as maintenance treatment in senile depressive patients.

关 键 词：舍曲林 老年 抑郁疗 依从性 复发率 

分 类 号：R749.4[医药卫生—神经病学与精神病学]