胃癌组织内微血管定量的意义  

The significance of microbloodvessel quantitation in gastric cancer

作　　者：陶厚权[1] 秦兰芳[2] 林言箴[1] 

机构地区：[1]上海第二医科大学瑞金医院外科,200025 [2]上海第二医科大学病理教研室,200025

出　　处：《中华消化杂志》1997年第1期20-22,共3页Chinese Journal of Digestion

摘　　要：目的：研究胃癌组织中微血管数量（MVC）与临床病理因素及预后的关系。方法：材料取自瑞金医院1988年～1991年胃癌手术切除标本，共128例。抗因子Ⅷ相关抗原（F-ⅧRAg）的单克隆抗体和免疫组化试剂盒购自Dako公司。研究方法按LSAB法免疫组织化学操作技术常规进行；微血管定量以镜下200倍，肿瘤内5个最高微血管密度区的MVC均数表示；分析MVC与临床病理因素之间关系，并对有完整5年随访资料的86例胃癌患者预后与MVC关系进行探讨。结果：所有胃癌组织中的平均MVC为16.5±8．5，MVC随TNM分期增加而增加，有淋巴结转移患者的MVC（18．3±8.7）明显高于无淋巴结转移患者（13．8±7．4）（P＜0．01），高MVC（≥16）胃癌患者比低MVC（＜16）患者预后明显为差，5年生存率分别为42.5％和58．7％（P＜0．05）。结论：MVC在胃癌患者是一个有意义的预后指标．Objectives: To investigate the correlationship between microvessel quantitation,various clinicopathologic factors and prognosis of gastric carcinoma using immunohistochemical staining with anti-factor Ⅷ-related antigen (F-Ⅷ RAg) antibody- Methods:A total of 128 specimens resected from patients with gastric carcinoma were investigated by immunohistochemical staining with a monoclonal antibody against F-Ⅷ RAg. Correlations between the microbloodvessel count (the mean number of microvessel in the five areas of highest vascular density at 200×magnification),various clinicopathologic factors and prognosis of 86 cases with complete follow-up data were studied. Results: The mean microvessel count of all patients was 16.5±8.5, the mocrobloodvessel count increased with TNM staging and was significantly higher in patients with lymph node metastases than those without (P<0.01). Furthermore, the prognosis of 86 patients who were followed-up for at least 5 years after surgery was significantly worser in patients who had a tumor with high microvessel count (16 or greater) than in those with the lower one (less than 16)(P<0.05). Conclusions: Microvessel count may be a better prognostic indicator in patients with gastric carcinoma.

关 键 词：胃肿瘤 血管组织 预后 

分 类 号：R735.202[医药卫生—肿瘤]