原发性十二指肠癌细胞表面糖蛋白的变化与肿瘤生物学行为的关系  

The relationship between changes of cell surface glycoproteins of primary duodenal adenocarcinoma and its biological behaviors

作　　者：吕农华[1] 徐萍[1] 吴斌 王崇文[1] 

机构地区：[1]江西医学院第一医院南昌市,330006

出　　处：《中华消化杂志》1997年第2期82-84,共3页Chinese Journal of Digestion

摘　　要：目的：探讨原发性十二指肠癌细胞表面糖蛋白的变化与肿瘤生物学行为的关系。方法：采用ABC免疫组化的方法，以PHA作探针，标记十二指肠癌细胞，观察其表面PHA受体的表达。结果：（1）伴有淋巴结转移的十二指肠癌细胞PHA受体的表达率（88．9％）明显高于无淋巴结转移的癌细胞（45．5％，P＜0．05）。（2）PHA受体的表达与肿瘤浸润十二指肠壁的程度有密切关系，浸润越深，PHA受体表达率越高（P＜0．05）。（3）十二指肠癌的病理类型与PHA受体的表达未见明显关系。结论：十二指肠癌细胞表面糖蛋白的改变与肿瘤的生物学行为关系密切，PHA受体过度表达的十二指肠癌细胞具有转移的潜力，易于发生局部的浸润和淋巴结的转移。Objectives: To observe the relationship between the tumor cell surface glycoproteinand tumor biological behaviors in primary duodenal adenocarcinoma. Methods: Immunohistochem－ical studies with PHA, as a molecular probe for glycoproteins, (ABC method) were performed ontissues of duodenal adenocarcinoma from 29 patients. Results: 1. The rate of PHA receptor expression in duodenal adenocarcinoma with lymph node metastases (88.9％) was significantlyhigher than that without (45.5％, P＜0.05); 2. The degree of PHA receptor expression was related toinvasiveness of duodenal carcinoma, that is, the more serious the invasiveness, the higher the PHAexpression rate; 3. There was poor correlation between the PHA expression and pathological typesof duodenal carcinoma. Conclusions: The changes of cell surface glycoproteins are closely related to the biological behaviors of duodenal adenocarcinoma; the tumor cells with overexpression ofPHA receptor have metastatic potential, which easily invade its surrounding tissues and developlymph node metastases.

关 键 词：十二指肠肿瘤 生物学行为 糖蛋白 原发性 

分 类 号：R735.310.2[医药卫生—肿瘤]