Synthesis of derivatives of imidazo[4,5-b]pyridine:Novel sulfur contained side chains for macrolide antibiotics  

作　　者：Lu Liu Peng Xu Liang Zhou Ping Sheng Lei 

机构地区：[1]Key Laboratory of Bioactivity Substance and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Peking Union Medical College ＆ Chinese Academy of Medical Science, Beijing 100050,China

出　　处：《Chinese Chemical Letters》2008年第1期1-4,共4页中国化学快报（英文版）

基　　金：Finacial support of this research by the National Natural Science Foundation of China （No. 30572275） ；Natural Science Foundation of Beijing （No. 7062047） are gratefully acknowledged by the authors.

摘　　要：Two series of novel derivatives of imidazo[4,5-b]pyridine were synthesized. These compounds could be used as side chains of semisynthesised ketolide antibiotics. The side chains have free amine group which can attached to ketolide core. Macrolides with this kind of side chains will show obvious activities against erythromycin-resistant strains. The structure of the side chains was confirmed by ^1H, ^13C NMR, MS, HMBC spectra. 2007 Ping Sheng Lei. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.Two series of novel derivatives of imidazo[4,5-b]pyridine were synthesized. These compounds could be used as side chains of semisynthesised ketolide antibiotics. The side chains have free amine group which can attached to ketolide core. Macrolides with this kind of side chains will show obvious activities against erythromycin-resistant strains. The structure of the side chains was confirmed by ^1H, ^13C NMR, MS, HMBC spectra. 2007 Ping Sheng Lei. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关 键 词：MACROLIDE Heterarylalkyl sulfur contained side chain Imidazo[4 5-b]pyridine Synthesis HMBC 

分 类 号：O626[理学—有机化学]