肾癌根治术后生物化疗的临床观察  

Effect of biochemotherapy after radical nephrectomy for patients with renal cell carcinoma

作　　者：王蕾[1] 孙志华[1] 易铁男[1] 张晓灵[1] 

机构地区：[1]华中科技大学同济医学院附属襄樊医院肿瘤科,湖北襄樊441021

出　　处：《现代肿瘤医学》2008年第3期415-416,共2页Journal of Modern Oncology

摘　　要：目的:探讨生物化疗在肾癌根治术后的治疗作用。方法:对69例行肾癌根治术后的患者按治疗方法分为A、B两组,A组术后用α-干扰素和5-氟尿嘧啶,B组用白细胞介素-2、α-干扰素和5-氟尿嘧啶联合治疗。比较两组术后生存率。结果:通过随访比较,两组早期(I-II期)肾癌根治术后患者1年-3年生存率差异无显著性(P>0.05),晚期(III期)肾癌根治术后患者3年生存率差异有显著性(P<0.05)。所有患者没有发生严重毒副反应。结论:白细胞介素-2、α-干扰素联合5-氟尿嘧啶对晚期肾癌有效,疗效优于仅用α-干扰素和5-氟尿嘧啶。Objective：To evaluate the effect of biochemotherapy on the treatment of renal cell carcinoma after radical nephrectomy. Methods： A total of 69 patients with renal cell carcinoma were divided into two groups by therapeutic methods. Only interferon - a and 5 - fluorouracil were used in group A; in group B, interleukin - 2 combined with interferon - a and 5 - fluorouracil were used after operation. The survival rate was compared between the two groups. Results： The difference of 1 - , 2 - and 3 - year survival rate of the patients in early - stage （ stage Ⅰ and Ⅱ） renal cell carcinoma between the two groups had no significance （P 〉 0. 05 ）. There was a significant difference in 3 - year survival rate between the two groups in advanced （ stage Ⅲ） renal cell carcinoma （P 〈 0. 05 ）. There was no severe toxicity. Conclusion： Interleukin - 2, interferon - α and 5 - fluorouracil combination therapy was effective for advanced renal cell carcinoma, which was better than interferon - α and 5 - fluorouracil.

关 键 词：肾细胞癌 肾癌根治术 生物化疗 

分 类 号：R737.11[医药卫生—肿瘤]