宫颈癌整合素β_1的表达及微血管密度与其侵袭性的关系  

Expression and invasive effect of Integrin β_1 and microvessel density in cervical carcinoma

作　　者：詹平[1] 毛熙光[1] 董述全[1] 张宇骄[1] 伍宗惠[1] 

机构地区：[1]泸州医学院附属医院妇产科,四川泸州646000

出　　处：《现代肿瘤医学》2008年第3期417-420,共4页Journal of Modern Oncology

基　　金：泸州医学院基金资助项目(编号:06120)

摘　　要：目的:探讨整合素β1(INTβ1)及微血管密度(MVD)在宫颈癌浸润和转移中的作用机制。方法:采用免疫组织化学SP法,分别测定12例正常宫颈、14例宫颈原位癌、56例宫颈浸润癌组织中INTβ1的表达及MVD。结果:宫颈浸润癌INTβ1的阳性表达与原位癌和正常宫颈比较有明显差异(P=0.000)。宫颈浸润癌MVD与原位癌和正常宫颈比较有明显差异(P=0.000)。宫颈癌Ⅱ期INTβ1的阳性表达和MVD分别与Ⅰ期比较,有统计学差异(P=0.006)。组织学分级G3INTβ1的阳性表达及MVD与G1比较有明显差异(P=0.010;P=0.000)。宫颈癌淋巴结转移组INTβ1与无淋巴结转移组比较有明显差异(P=0.018),而MVD比较无差异(P=0.197)。结论:在宫颈癌发生、发展中,INTβ1表达增强和微血管密度增高可能发挥了重要作用,有望作为观察宫颈癌进展的重要参考指标。Objective：To evaluate the immunohistochemical expressions of integrinβ1 （INTβ1 ） and microvessel density（MVD） in cervical cancer, and reveal the possible mechanism in the invasion and metastasis of cervical carcinoma. Methods： In 12 normal cervical epithelia （NCE） cases,14 cervical carcinoma in situ （CIS） cases and 56 invasive cervical carcinoma （ICC） cases, immunohistochemical S - P method was used to examine the expression levels of INTβ1 and MVD. Results： The expression level of INTβ1 was significantly higher in ICC than in CIS and NCE（P =0.000）. The MVD was significantly higher in ICC than in CIS and NCE（P=0.000）. In comparison to stage Ⅰ ICC, the expression levels of INTβ1 and MVD in stage Ⅱ were significanfluy different （ P = 0. 006 ; P = 0.006）. In comparison to G1 ICC, the MVD and the expression level of INTβ1 in G3 had significant difference （P =0.010;P =0.000）. In comparison to the without lymph nodal metastasis group, the expression levels of INTβ1 in ICC with lymph node metastasis group were significantly different（P = 0. 018）, but the MVD was no significant difference（ P = 0. 197）. Conclusion： INTβ1 might have a key role in the invasion and metastasis of cervical carcinoma. The increase of microvessel density is closely related to the progression of tumor. Their levels maybe act as clinical referential indexes in the progression of cervical carcinoma.

关 键 词：宫颈癌 整合素Β1 微血管密度 肿瘤转移 

分 类 号：R737.33[医药卫生—肿瘤]