缺氧诱导因子-1与脑缺血缺氧性损伤研究进展  

Study Progress of Hypoxia Inducible Factor-1 and Cerebral Ischemic-hypoxic Injuries

作　　者：刘乔飞[1] 冯超[1] 隆艳艳[1] 冯林[1] 车永哲[1] 

机构地区：[1]南开大学医学院,天津300071

出　　处：《亚太传统医药》2008年第2期23-28,共6页Asia-Pacific Traditional Medicine

基　　金：南开大学"百项工程"

摘　　要：缺氧诱导因子-1(hypoxia-inducible factor-1,HIF-1)是目前发现的最重要的缺氧感受因子。它作为一种转录调节因子,在脑缺血缺氧状态下,可激活100多种缺氧反应性基因表达,对脑缺血缺氧后微血管的再生、神经元的能量代谢、神经干细胞的增殖、分化的调控起到重要作用。但最近又发现,HIF-1是介导脑缺血缺氧后炎症损伤的关键因子,同时参与脑缺血缺氧后神经元的迟发性死亡。对近5年来国内外HIF-1与脑缺血缺氧性损伤的相关研究成果进行综述。Hypoxia-inducible factor-1 （HIF-1） is the most important hypoxia sensor found in the body. As a transcription regulator, it can enhance more than 100 hypoxic reactive genes expression under the hypoxia state. It can promote anagenesis, regulate neuro-stem cells proliferation/differentiation and improve the energy metabolism of the neurons after cerebral ischemic-hypoxic injuries, however, recently, someone has found that it also can aggravate the inflammatory injuries and induce the delayed death of neurons. In this article, we reviewed the progress of hypoxia inducible factor-1 and cerebral ischemic-hypoxic injuries in the past five years.

关 键 词：缺氧诱导因子-1 脑缺氧缺血性损伤 缺氧反应性基因 

分 类 号：R743[医药卫生—神经病学与精神病学]