癫痫患者语义加工的功能磁共振成像研究  

Semantic Processing in Patients with Epilepsy Studied by fMRI

作　　者：李新宇[1] 王荫华[1] 王薇薇[1] 吴逊[1] 

机构地区：[1]北京大学第一医院神经内科,北京市100034

出　　处：《中国康复理论与实践》2008年第2期135-137,F0003,共4页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：目的分析颞叶癫痫(TLE)患者语义处理相关功能区的分布。方法左侧TLE患者、右侧TLE患者和健康对照各6例,均为右利手。对所有受试者进行逆序词任务功能性磁共振成像(fMRI)检查,以按键记录受试者反应,使用统计参数图2(SPM2)对fMRI图像进行个体水平的统计分析和组分析。结果右侧TLE患者主要激活左侧的额下回、额中回、颞上回、颞中回以及双侧扣带回、梭状回、基底节区、小脑(右著)等区域,与对照组的差异无显著性意义;左侧TLE患者与对照组相比语言激活区出现不典型化表现,右侧额下回、中央前回和左侧楔叶、楔前叶出现更多激活。结论左侧TLE患者的语义处理相关功能区不典型分布,出现激活区对侧镜像转移。Objective To reveal the cerebral activation areas related to semantic processing of language functions in patients with temporal lobe epilepsy （TLE）. Methods 6 patients with left-TLE, 6 patients with right-TLE, and 6 controls, all right-handed, were studied using functional magnetic resonance imaging （fMRI） during a reversible words decision task. Their responses were recorded by key-press. The image data was analyzed by statistical parametric mapping 2 （SPM2） including the individual statistical analysis and group analysis. Results There was no difference between the right-TLE patients and controls in cerebral activation, which included left inferior frontal gyrus, left middle frontal gyrus, left superior temporal gyrus, left middle temporal gyrus and bilateral cingulate gyrus, bilateral fusiform gyrus, bilateral basal ganglia, bilateral cerebellum （especially right）. The activation in patients with left-TLE was atypically distributed relative to the controls, there were more activation in right inferior frontal gyrus, right precentral gyrus and left cuneus, left precuneus. Conclusion There is atypical distribution of the cerebral activation area related to semantic processing of language functions in patients with left-TLE, and enantiomorphous transformation is found in the contrelateral side of cerebrum.

关 键 词：癫痫 功能性磁共振成像 语言 逆序词 

分 类 号：R749.1[医药卫生—神经病学与精神病学]