复发性脑梗死患者尿11-DH-TXB2水平测定  

Assay of urine 11-DH-TXB2 in patients with recurrent cerebral infarction

作　　者：郭淮莲[1] 程敏[1,1] 唐文雄[1] 黄丽[1] 吴俊[1] 

机构地区：[1]北京大学人民医院,北京100044

出　　处：《山东医药》2008年第1期22-23,共2页Shandong Medical Journal

摘　　要：目的观察复发性脑梗死患者尿11-去氢-血栓烷B2(11-DH-TXB2)水平变化。方法复发性脑梗死患者26例,初发脑梗死患者30例,均于入院时及服用阿司匹林7 d后各留取尿标本1次;非脑血管病性患者28例作为对照组,留取尿标本1次。酶免疫法(EIA)测定尿11-DH-TXB2水平。结果复发组及初发组入院时尿11-DH-TXB2均高于对照组(P<0.05),服用阿司匹林后尿11-DH-TXB2水平均较服药前显著下降(P<0.01);复发组与初发组阿司匹林抵抗发生率无统计学差异(P>0.05)。结论复发及初发脑梗死患者急性期尿11-DH-TXB2水平均升高。阿司匹林可显著降低急性脑梗死患者尿11-DH-TXB2水平。Objective To investigate the change of urine 11-dehydro-thromboxane B2 （ 11-DH-TXB2 ） in patients with recurrent cerebral infarction. Methods Urine samples were collected before and after aspirin intake （ 100 mg/day, 7 days） in 26 patients with recurrent cerebral infarction （ group A） and 30 patients with first-ever cerebral infarction （ group B ） , while only one sample was collected in 28 non-stroke patients （ group C）. Urine 11-DH-TXB2 was measured with the method of EIA. Results The urine 11-DH-TXB2 levels in group A and group B on admission were significantly higher than that in group C （P〈0.05）. The urine ll-DH-TXB2 levels decreased significantly after the use of aspirin in group A and group B （ P 〈 0.01 ）. The difference of the rates of aspirin resistance between group A and group B was not significant （ P 〉 0.05 ）. Conclusions The urine 11 -DH-TXB2 levels are increased in both recurrent and first-ever cerebral infarction patients. Aspirin can reduce the urine 11-DH-TXB2 levels significantly in infarction patients.

关 键 词：复发性脑梗死 11-去氢-血栓烷B2 阿司匹林抵抗 

分 类 号：R743.3[医药卫生—神经病学与精神病学]