NF-κB、P-gp、c-erbB-2蛋白在乳腺癌组织中的表达及意义  

Expression of NF-κB,P-gp and c-erbB-2 and its clinical significance in breast cancer

作　　者：崔涛[1] 朱祖安[2] 刘莹[1] 杨雪梅[1] 

机构地区：[1]徐州医学院,江苏徐州221002 [2]徐州市中心医院

出　　处：《山东医药》2008年第1期33-35,共3页Shandong Medical Journal

基　　金：江苏省高校自然科学基金(05KJD320234);徐州市科技计划项目(06-34)

摘　　要：目的探讨核因子κB(NF-κB)、P-gp、c-erbB-2蛋白在乳腺癌组织中的表达及其临床意义。方法采用免疫组化Power visionTM两步法检测97例乳腺癌组织中NF-κB、P-gp、c-erbB-2的表达情况。结果乳腺癌组织中NF-κB、P-gp、c-erbB-2的阳性表达率分别为65.97%、43.29%、50.51%;NF-κB、c-erbB-2与乳腺癌淋巴转移及病理分期相关(P<0.05);在乳腺癌标本中NF-κB、P-gp、c-erbB-2蛋白表达两两间均有相关性(P<0.05)。结论乳腺癌中NF-κB、P-gp、c-erbB-2三者间蛋白表达均有相关性,其在乳腺癌多药耐药发生中具有一定作用。Objective To explore the expression of nuclear transcription factor （ NF-κB）, P-gp and c-erbB-2 in breast cancer and its clinical significance. Methods The expressions of NF-κB, P-gp and c-erbB-2 were determined with immunohistochemistry （Power VisionTM two step methods） in 97 human breast cancer. Results The expression of NF-κB, P-gp, c-erbB-2 in breast cancer tissues was 65.97%, 43.29%, 50. 51% respectively. Overexpression of NF-κB and c- erbB-2 in breast cancer was related to histological grading and lymph node metastasis （ P 〈 0. 05 ）. Expression of NF-κB in breast cancer tissues was positively correlated with P-gp and c-erbB-2 expression （P 〈 0.05 ）. Conclusion The expression of NF-κB in breast cancer tissues is positively correlated with P-gp and c-erbB-2 expression, and it may play a synergistic role in the MDR of breast cancer.

关 键 词：NF-ΚB P—gp c—erbB-2 乳腺肿瘤 

分 类 号：R737.9[医药卫生—肿瘤]