丹参抗肝纤维化作用机制研究进展  

Research Progress in Anti-Hepatic Fibrosis Effects of Salvia Miltiorrhiza

作　　者：李新荣[1] 胡坚方[1] 

机构地区：[1]江西省人民医院消化内科,江西南昌330006

出　　处：《现代诊断与治疗》2008年第1期30-33,共4页Modern Diagnosis and Treatment

摘　　要：肝纤维化是多种病因所致慢性肝炎的共同病理变化,特征在于肝脏细胞外基质异常增生与过度沉积,其核心环节在于肝星状细胞的活化。近年来,丹参及其有效成分在抗肝纤维化研究中取得了许多进展。丹参抗肝纤维化作用机制主要有:抗自由基过氧化损伤、促进损伤肝细胞的修复、抑制炎性因子释放、改善肝脏微循环、抑制胶原生成、促进病理沉积胶原的降解、抑制HSC活化。Hepatic fibrosis is a common pathological change of chronic hepatitis resulted from etiopathogenisis with the characteristic of paraplasm and excessive deposition of extracellular a variety meterical （ECM） ,the core of which is activation of hepatic sellate cell.In recent years,the research of salvia miltiorrbiza and its active components about depressing hepatic fibrosis has made a great progress.The main mechanism of depressing production of collagen, promoting degradation of liver,depressing production of collagen,promoting degradation of collagen deposited in pathologicl process and depressing the activation of HBC.

关 键 词：丹参 肝纤维化 作用机制 

分 类 号：R575.59[医药卫生—消化系统]