APE/Ref-1基因单核苷酸多态性与肿瘤关系的研究进展  

Progress on the Correlationship of Single Nucleotide Polymorphisms of APE/Ref-1 with cancer

作　　者：郑智华[1] 黄爱民[1] 

机构地区：[1]福建医科大学基础医学院病理学系

出　　处：《医学综述》2008年第3期340-342,共3页Medical Recapitulate

基　　金：福建省自然科学基金项目(C0610021;2006J0099)

摘　　要：脱嘌呤/脱嘧啶核酸内切酶1(APE1)是一个生物大分子功能复合体,既具有脱嘌呤/脱嘧啶位点(AP位点)核酸内切酶活性,又具调节转录因子的活性。其分布及单核苷酸多态性为近年来研究的热点。探讨其单核苷酸多态性与肿瘤的关系将有助于对肿瘤的防治。Apurinc/apyrimidinic endonuclease 1/redoxfactor 1 is a functional complexity of a biological macromolecule, with both endonuclease activation for apurinc/apyrimidinic sites and mediating ability of transcription factor. In recent years, it is hot on the research of its distribution and SNPs. In this aritcle, we mainly reviewed advances in the correlationship study of the single nucleotide polymorphisms with cancer. It will be helpful in prevention and control of cancer to study on the relationship between its SNPs and cancer.

关 键 词：基因 脱嘌呤/脱嘧啶核酸内切酶1 氧化还原因子1 单核苷酸多态性 

分 类 号：Q754[生物学—分子生物学] R73[医药卫生—肿瘤]