牙周炎患者颈动脉内膜中层厚度与肱动脉内皮依赖性血管扩张功能的观察  

Observation on the intima media thickness of the carotid artery and endothelium-dependent vascular dilation function of brachial artery in patients with periodontiti

作　　者：关晶[1] 杜荣品[2] 宋维来[3] 

机构地区：[1]河北省人民医院口腔科,石家庄市050051 [2]河北省人民医院心内科,石家庄市050051 [3]卫生部北京医院口腔科

出　　处：《河北医药》2008年第1期25-27,共3页Hebei Medical Journal

摘　　要：目的探讨中、重度牙周炎与血管内皮功能障碍及颈动脉内膜中层厚度的相关关系。方法本研究共76例,牙周炎组41例,对照组35例。分别用血管超声评估血流介导和硝酸甘油介导的肱动脉扩张值和颈动脉内膜中层厚度。结果与正常对照组相比,牙周炎组患者血流介导的肱动脉扩张明显减低[牙周炎组:(0.2±0.1)mm,对照组:(0.3±0.1)mm,P<0.01]。而在硝酸甘油介导的肱动脉扩张方面,2组之间差异无统计学意义[牙周炎组:(0.8±0.4)mm,对照组:(0.7±0.3)mm,P>0.05];与正常对照组比较牙周炎组患者颈动脉内膜中层厚度也明显增厚[牙周炎组:(1.1±0.4)mm,对照组:(0.9±0.4)mm,P<0.05]。结论牙周炎的患者存在血管内皮功能障碍,其颈动脉内膜中层也较对照组增厚,这些均是动脉粥样硬化的高危标志。Objective To investigate the correlation between moderate and severe periodontitis and vascular endothelial dysfunction as well as intima media thickness （IMT） of carotid artery （CA）. Methods 41 patients with periodontitis（periodontitis group） and 35 healthy subjects （control group）were enrolled in the investigation. The IMT of CA, blood flow-mediated braehial artery dilation numerical value and nitroglycerin-mediated braehial artery dilation numerical value were detected by vascular ultrasound. Results As compared with that in control group, blood flow-mediated braehial artery dilation numerical value in periodontitis group was significantly decreased[ （0.3±0.1 ）mm vs （0.2±0.1 ） mm, P 〈 0.01 ]. However there was no significant difference in nitroglycerin-mediated braehial artery dilation numerical value between two groups[ （0.8± 0.4） in periodontitis group vs （0.7±0.3 ）mm in control group, P 〉 0.05 ]. As compared with that in control group, the IMT of CA in periodontitis group was significantly increased [（0.9±0.4）ram vs （1.1±0.4）mm, P 〈0.05] .Conclusion The vascular endothelial dysfunction exists in patients with periodontitis, whose IMT of CA is obviously increased, which are the risk factors of arteriosclerosis.

关 键 词：牙周炎 动脉粥样硬化 动脉内膜 中层厚度 血管扩张 

分 类 号：R587.2[医药卫生—内分泌] R541.4[医药卫生—内科学]