合成2-芳氧基-5-氟-3H-4-嘧啶酮的新方法  

A New Method for Preparing 2 Aryloxy 5 fluoro 3H 4 pyrimidone

作　　者：孙昌俊[1] 王义贵[1] 戚聿新[1] 李洪祥[1] 陈再成[1] 张建国[2] 

机构地区：[1]山东大学化学系 [2]青岛海洋大学化学系

出　　处：《合成化学》1997年第1期61-63,共3页Chinese Journal of Synthetic Chemistry

摘　　要：由２－氯－５－氟－３Ｈ－４－嘧啶酮和取代苯酚钠在常压下反应，合成了７个未见文献报道的２－芳氧基－５－氟－３Ｈ－４－嘧啶酮化合物，产率７０～８７％，结构经ＩＲ、１ＨＮＭＲ和ＭＳ证实。A new method for preparing 2 aryloxy 5 fluoro 3H 4 pyrimidone was reported in this paper. The reaction of 2 chloro 5 fluoro 3H 4 pyrimidone and sodium aryloxide under normal pressure at 160℃ for 2h, gives seven new compounds in higher yield. Their structures were confirmed by IR, 1H NMR and MS.

关 键 词：氟脲嘧啶 抗癌药 亲核取代反应 合成 嘧啶酮 

分 类 号：O626.41[理学—有机化学] TQ463.54[理学—化学]