背根神经节在疼痛机制和治疗中的作用  

Effects of dorsal root ganglia on the pain mechanisms and treatments

作　　者：姜雨鸽[1] 徐龙河[1] 张宏[1] 

机构地区：[1]中国人民解放军总医院麻醉科,北京100853

出　　处：《国际药学研究杂志》2008年第1期18-22,共5页Journal of International Pharmaceutical Research

基　　金：国家自然科学基金资助项目(No.30300327)

摘　　要：背根神经节作为痛觉传入的第一级神经元在痛觉的外周机制中起着极为重要的作用。对背根神经节中特有的或者主要在背根神经表达的受体、离子通道的认识,对于阐明疼痛的机制和治疗有重要意义。本文对感觉神经元特有的Nav1.8通道,主要在背根神经节表达的Nav1.7,Nav1.9,TRPV1,TRPA1,TRPM8通道及P2X3受体的分布、生理特点及在疼痛机制和治疗中的作用进行了详细的阐述。As the primary afferent neurons of pain, dorsal root ganglias play very important roles in pcripheral mechanisms of pain. Cognition of the receptors and ion channels specifically or mainly expressed on dorsal root ganglias sing targets of analges can help us know the mechanisms of the pain and provide new thoughts for chooics. This review focuses on the distribution, physiological features and important effects on pain mechanisms and treatments of Nav1. 8 that is exclusively expressed on sensory neurons, Nav1. 7, Nav1. 9, TRPV1 ,TRPA1 ,TRPM8 and P2X3 that are mainly expressed on dorsal root ganglias .

关 键 词：神经节 脊 离子通道 疼痛 感受器 感觉 

分 类 号：R741[医药卫生—神经病学与精神病学]