抑癌基因P27^(kipl)蛋白与血管内皮生长因子在子宫内膜癌中的表达及其临床意义  

Expression of P27～(kipl) protein and vascular endothelial growth factor in carcinoma of endomertrium and its clinical significance

作　　者：肖健[1] 曹宁川[1] 吕振涛[1] 

机构地区：[1]沈阳市第五人民医院病理科,辽宁沈阳110023

出　　处：《中国肿瘤临床与康复》2008年第1期5-7,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨抑癌基因P27kipl蛋白与血管内皮生长因子(VEGF)联合标记在子宫内膜癌早期发现、早期诊断和判断预后中的应用价值。方法采用S-P免疫组化方法对66例子宫内膜癌、29例子宫内膜非典型增生、31例子宫内膜对照组织进行检测。结果在66例子宫内膜癌中,35例P27kipl蛋白表达呈阳性反应(53.0%),其中强阳性9例(13.6%);55例VEGF表达呈阳性反应(83.3%),其中强阳性16例(24.2%)。29例子宫内膜非典型增生病变中,22例P27kipl蛋白表达呈阳性反应(75.8%),其中强阳性8例(27.6%);14例VEGF表达呈阳性反应(48.3%),其中强阳性4例(13.8%)。31例子宫内膜对照组织中,27例P27kipl蛋白表达呈阳性反应(87.1%),其中强阳性16例(51.6%);3例VEGF表达呈阳性反应(9.7%),无强阳性。子宫内膜癌组P27kipl蛋白表达与正常子宫内膜对照组相比,差异有非常显著性(P<0.01);子宫内膜癌组与子宫内膜非典型增生病变组比较,差异有显著性(P<0.05);正常子宫内膜对照组与子宫内膜非典型增生病变组比较差异无显著性(P>0.05)。子宫内膜癌组VEGF表达与子宫内膜非典型增生病变组比较,差异有显著性(P<0.05);子宫内膜对照组与子宫内膜癌及子宫内膜非典型增生病变组比较,差异均有非常显著性(P<0.01)。结论P27kipl蛋白和VEGF在肿瘤生长、浸润等方面有重要作用,将它们进行联合检测,对肿瘤的早期发现、早期诊断、判断预后有重要意义。Objective To study the expression of P27^kipl protein and VEGF,and investigate their clinical significance in carcinoma of endometrium. Methods The S-P immunohistoehemieal method was used to detect the expression of P27^kipl in tissue samples of 66 carcinomas of endometrium,29 atypical hyperplasia of endometrium and 31 normal endometrium controls. Results There was significant difference between carcinoma of endometrium and normal endometrium controls （P 〈 0.01 ）. There was significant difference between carcinoma of endometrium and atypical hyperplasia of endometrium（P 〈 0.05 ）. There was no difference between atypical hyperplasia of endometrium and normal endometrium controls. Conclusions The results indicated that the detection of P27^kipl protein and VEGF was valuable for early discovery, early dignosis and judgement of prognosis of tumors in clinical work.

关 键 词：P27^KIPL蛋白 VEGF 子宫内膜癌 免疫组织化学 早期诊断 

分 类 号：R737.33[医药卫生—肿瘤] R730.43[医药卫生—临床医学]