ι-四氢巴马汀抑制羟考酮引起小鼠行为敏化的实验研究  

Studies on effects of ι-tetrahydropalmatine on locomotor sensitivity induced by oxycodone in mice

作　　者：刘艳丽[1] 颜玲娣[1] 亓佳[2] 吴春福[2] 宫泽辉[1] 

机构地区：[1]军事医学科学院毒物药物研究所新药评价实验室 [2]沈阳药科大学药理学教研室,辽宁沈阳110016

出　　处：《中国药理学通报》2007年第12期1613-1617,共5页Chinese Pharmacological Bulletin

基　　金：解放军总后"十五"指令性课题(No01L038)

摘　　要：目的探讨ι-四氢巴马汀(-tetrahydropalmatine,ι-THP)对羟考酮(oxycodone,oxy)行为敏化的影响和作用机制。方法采用连续7d给小鼠注射羟考酮(5mg.kg-1,ip),停药5d,d13用相同剂量的羟考酮(5mg.kg-1,ip)激发致小鼠行为敏化模型,利用红外光束自主活动测定仪测定小鼠自发活动的实验方法。结果ι-THP(6.25,12.5,18.75mg.kg-1,ig)一次或多次给药,对小鼠的自发活动没有影响,但ι-THP(18.75mg.kg-1,ig)能抑制羟考酮(5mg.kg-1,ip)引起的小鼠行为敏化的形成和表达。阿朴吗啡(0.5、1.0mg.kg-1,ip)给药后50min自身不影响小鼠的自发活动,但阿朴吗啡(1.0mg.kg-1,ip)能翻转ι-THP(18.75mg.kg-1,ig)抑制羟考酮小鼠行为敏化形成的作用,但不影响ι-THP抑制羟考酮行为敏化表达的作用。结论ι-THP抑制羟考酮引起的小鼠行为敏化的形成和表达,ι-THP抑制羟考酮行为敏化的形成可能与抑制DA受体相关,而抑制表达可能与抑制DA受体无关。Aim To investigate effects of ι-tetrahydropalmatine on locomotor sensitivity induced by oxycodone in mice and its mechanisms. Mothods Mice were administered for 7consecutive days with oxycodone （5 mg·kg^-1 ,ip）. After 5 d withdrawal period, all animals were injected with oxycodone （5 mg·kg^-1） and then put into the test chambers to record their locomotor activities for 60 rain. Results ι-THP did not affect the locomotor activity per set, but ι-THP （18. 75 mg·kg^-1 ,ig）inhibited the development and expression of locomotor sensitivity induced by oxycodone in mice;apomorphine（0. 5, 1.0 mg·kg^-1, ip） did not affect the locomotor activity per set, but apomorphine could sheerly inhibited the effects of ι-THP on the development of the locomotor sensitivity by oxycodone, and there were no effects of ι-THP on the expression of the locomotor sensitivity. Conclusions ι-THP inhibited the deveolpment and expression of locomotor sensitivity induced by oxycodone in mice, and the meschanims of ι-THP on the deveolpment of locomotor sensitivity might be correlated with DA receptor, but the meschanims of ι-THP on the sensitivity expression might not be involved.

关 键 词：ι-四氢巴马汀 羟考酮 行为敏化 DA受体 

分 类 号：R-332[医药卫生] R284.1