肝纤维化过程中血液动力学因素对肝星状细胞的影响  

Influence of hemodynamic factors on hepatic stellate cells during hepatic fibrosis

作　　者：陈骧[1] 徐世荣[1] 吴云鹏[1] 

机构地区：[1]重庆大学生物工程学院,重庆市400044

出　　处：《世界华人消化杂志》2008年第2期185-191,共7页World Chinese Journal of Digestology

摘　　要：肝纤维化过程中,肝脏炎症、胞外基质纤维化、肝血窦毛细血管化等,无不对肝脏血流动力学造成影响,表现为肝内血流阻力增加、门脉高压出现等.在肝纤维化过程中,肝星状细胞发挥了关键作用.为了研究肝纤维化过程中肝星状细胞(HSC)所处环境的血液动力学因素变化对肝纤维化进程的影响,本文综合探讨肝纤维化发生、发展过程中肝脏血液流动力学变化及其对肝星状细胞激活、胞外基质表达、肝脏血管重建的作用,从生物力学的角度探讨纤维化机制,以达到进一步明确应力在肝纤维化过程中的作用.Hepatic stellate cells （HSCs） play a central role in the development of liver fibrosis. In liver fibrosis, intrahepatic resistance and splanchnic blood flow are increased. Inflammation, hepatic sinusoid capillarization, portal hypertension are very important factors in the hemodynamics of liver. In order to study the influence of hemodynamic factors on HSCs during hepatic fibrosis, this paper describes the activation and expression of extracellular matrix in HSCs as well as hepatic vascular reconstruction when changes occur in the hemodynamics of liver fibrosis, in terms of the biomechanics of liver fibrosis mechanism to further understand the role of stress in the process of hepatic fibrosis. Based on the large number of literatures, we can draw a conclusion that an appropriate level of mechanical stress can activate HSCs, produce extracellular matrix （ECM）, and accelerate liver regeneration.

关 键 词：炎症 肝星状细胞 血流动力学 机械应力 胞外基质 肝纤维化 

分 类 号：R575.2[医药卫生—消化系统] R657.34[医药卫生—内科学]