氦氖激光对体外人肝癌和胃癌细胞增殖的影响  

Effect of Helium neon Laser Irradiation on the in Vitro Proliferation of Human Hepatoma and Gastric Cancer Cells

作　　者：张文庚[1] 陈晓禾[1] 王艳萍[1] 徐刚[1] 陈传真 韩洪富 

机构地区：[1]华西医科大学肿瘤研究所

出　　处：《中华物理医学杂志》1997年第2期69-71,共3页Chinese Journal of Physical Medicine and Rehabilitation

基　　金：国家自然科学基金

摘　　要：目的：研究氦氖激光的生物学效应。方法：用３４．５～１３８Ｊ／ｃｍ２的氦氖激光照射体外培养的人肝癌ＳＭＭＣ７７２１和人胃癌ＳＧＣ７９０１细胞，间日１次，共６次。结果：６９Ｊ／ｃｍ２和１３８Ｊ／ｃｍ２的氦氖激光照射人肝癌细胞后７２小时和９６小时内、３４．５～１３８Ｊ／ｃｍ２的氦氖激光照射人胃癌细胞后７２小时内有促进增殖的作用（Ｐ＜０．０５）。结论：较大剂量的氦氖激光照射人癌细胞后在一定时间内有促进其生长的作用，在临床应用上应避免该副作用的发生。Objective: To gain insight into the biological effects of helium neon laser on cells.Methods: Cultured human hepatoma and gastric cancer cells were treated to assess the effects of low energy helium neon laser irradiation( 34.5 ￣138 J/cm 2,once in every other day,for 6 times) on cell proliferation. Results:A significant stimulative effect on proliferation was found statistically in both hepatoma (69 J/cm 2 within 72 hours and 138 J/cm 2 within 96 hours post irradiation) and gastric cancer cells( 34.5 ￣138 J/cm 2 within 72 hours after irradiation)(P< 0.05 ). Conclusion : The results suggest that helium neon laser irradiation in patients with hepatoma and gastric cancer or after oncologic surgery could be potentially harmful as result of stimulating proliferation.

关 键 词：肝肿瘤 放射疗法 胃肿瘤 细胞转化 激光疗法 

分 类 号：R735.705[医药卫生—肿瘤] R735.205[医药卫生—临床医学]