Synthesis, DNA-binding, and Photocleavage of 2,3-Di-2-pyridylquinoxaline-silver(Ⅰ) Complex  

作　　者：WANG Xiu-li FANG Jia-ni BI Yan-feng LIN Hong-yan LIU Guo-cheng 

机构地区：[1]Faculty of Chemistry and Chemical Engineering, Liaoning Key Laboratry of Applied Chemistry, Bohai University, Jinzhou 121000, P. R. China

出　　处：《Chemical Research in Chinese Universities》2008年第1期15-19,共5页高等学校化学研究（英文版）

基　　金：Natural Science Foundation of Liaoning Province, China(No.20061073);Education Committee Foundation of Liaoning Province, China(No.22004F023)

摘　　要：A new dinuclear complex, [Ag（L）（CH3CN）]2（ClO4）2·2H2O（L=2,3-di-2-pyridylquinoxaline）, was prepared and characterized by elemental analyses, IR spectroscopy, and single-crystal X-ray diffraction analyses. The interaction of the complex with calf thymus DNA（CT-DNA） was investigated by absorption, fluorescence spectroscopies, and viscosity measurement. The results suggested that the complex was bound to DNA via an intercalative mode. The intrinsic binding constant value Kb was found to be approximately 1.48×10^3 L·mol^-1. Moreover, the Ag（I） complex could cleave the plasmid pUC19 DNA from the supercoiled Form Ⅰto the nicked FormⅡ under irradiation at 365 nm.A new dinuclear complex, [Ag（L）（CH3CN）]2（ClO4）2·2H2O（L=2,3-di-2-pyridylquinoxaline）, was prepared and characterized by elemental analyses, IR spectroscopy, and single-crystal X-ray diffraction analyses. The interaction of the complex with calf thymus DNA（CT-DNA） was investigated by absorption, fluorescence spectroscopies, and viscosity measurement. The results suggested that the complex was bound to DNA via an intercalative mode. The intrinsic binding constant value Kb was found to be approximately 1.48×10^3 L·mol^-1. Moreover, the Ag（I） complex could cleave the plasmid pUC19 DNA from the supercoiled Form Ⅰto the nicked FormⅡ under irradiation at 365 nm.

关 键 词：DNA Ag-Polypyridyl complex Interaction Fluorescence CLEAVAGE 

分 类 号：Q523[生物学—生物化学] O636.1[理学—高分子化学]