脑梗死患者及健康者β纤维蛋白原基因启动子区HaeⅢ多态性与血浆纤维蛋白原浓度比较及性别间差异分析  

Comparison of β fibrinogen gene HaeⅢ polymorphisms and plasma fibrinogen in men and women with cerebral infarction patients and the healthy

作　　者：朱莉[1] 于凤秀 韩永涛[1] 刘文君[1] 周盛年[1] 

机构地区：[1]山东大学齐鲁医院神经内科,山东济南250012 [2]长春中西医结合医院

出　　处：《中国老年学杂志》2008年第3期274-276,共3页Chinese Journal of Gerontology

摘　　要：目的分析比较脑梗死(CI)及健康者β纤维蛋白原基因启动子区HaeⅢ(βHaeⅢ)多态性和血浆纤维蛋白原浓度的性别间差异。方法对102名发病10d内的CI患者(男61例,女41例)和53名查体者(男35例,女18例)用聚合酶链反应(PCR)和限制性片段长度多态性(RFLP)的方法,分析受试者的基因型,用Follin酚法测定纤维蛋白原的浓度。结果在CI患者和健康者中,βHaeⅢ多态性分布频率存在性别间差异。女性H1H2杂合基因型比例高于男性(P<0.05),男性表现为H2H2纯合基因型(CI组比对照组为0.99比0.29),女性未发现H2H2基因型(P<0.05)。CI组男性血浆纤维蛋白原浓度较女性高〔(3.8±0.8)g/Lvs(3.1±0.3)g/L,P<0.05〕。结论无论是CI患者还是健康人群,βHaeⅢ多态性分布频率存在性别间差异。Objective To compare the difference of β fibrinogen gene HaeⅢ polymorphisms and plasma fibrinogen levels between men and women with cerebral infarction （CI） and normal individuals. Methods The genotypes and fibrinogen levels of 102 CI patients （61 men,41 women） within 10 days after the event and fifty three controls （35 men,18 women） were determined by PCR and RFLP and Follin phenol method respectively. Results The difference of βHaeⅢ polymorphism＇s frequency between men and women was significant The frequency of HIH2 genotypes in female was higher than that of male（P 〈0. 05）. H2H2 genotypes were found in men （ CI vs controls：0. 99 vs 0. 29 ）. No H2H2 genotypes were discovered in women （ P 〈 0. 05 ）. Plasma fibrinogen levels in men were higher than those in women [ CI ： （3. 8 ±0. 8） g/L vs （3.1 ±0. 3） g/L,P〈0.05]. Conclusions There is indeed difference in β fibrinogen HaeⅢ gene polymorphisms frequencies and plasma fibrinogen levels between men and women either in CI or normal individals.

关 键 词：脑梗死 性别 βHaeⅢ 多态现象(遗传学) 纤维蛋白原 

分 类 号：R743.33[医药卫生—神经病学与精神病学]