乳腺富糖原透明细胞癌临床病理特点  

Clinicopathologic characteristics of glycogen-rich clear cell carcinoma of the breast

作　　者：于泳[1] 傅西林[1] 牛昀[1] 刘君[1] 藏凤琳[1] 

机构地区：[1]天津医科大学附属肿瘤医院乳腺病理研究室,300060

出　　处：《临床与实验病理学杂志》2008年第1期40-42,共3页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的探讨乳腺富糖原透明细胞癌的临床病理特点和鉴别诊断要点。方法观察11例乳腺富糖原透明细胞癌临床病理和免疫组化标记结果,并复习相关文献。结果患者发病年龄31～73岁,中位48岁。临床均表现为乳腺实性肿块,全部行改良根治术,经随访3～52个月,病人均健在,无复发和远处转移。乳腺富糖原透明细胞癌形态学特点:癌细胞为多边形或柱状,细胞边界清楚,可排列成巢状、片状或乳头状,超过90%的癌细胞胞质透明,其内富含糖原,PAS染色(+)。免疫组化染色显示:癌细胞CK(+),CEA、NSE、S-100蛋白、actin、vimentin均(-),约50%病人ER、PR(+)。结论乳腺富糖原透明细胞癌是一种少见的特殊型乳腺癌,其诊断主要依靠组织病理学和免疫组化标记,生物学特性有待于进一步观察。Purpose To explore the clinicopathologic characteristics and differential diagnosis of glycogen rich clear cell carcinoma （GRCC） in the breast. Methods Eleven cases of GRCC in the breast were analyzed for correlation of clinicopathologic characteristics with immunohistochemical findings. The correspondent literature was then reviewed. Resets Patients median age was 48 years old （31 ～73 yrs）. All of the cases were shown a single mass in the breast at diagnosis and treated with a modified radical mastectomy. Followed - up for 3 ～ 52 months, all the patients were alive without recurrence and distant metastasis. Histologically, GRCC cells were polygonal and column- like, which tended to have sharply defined border and formed solid tumor nests, sheets, or papillary structures. More than 90% of the neoplastic cells had abundant clear cytoplasm containing glycogen and were positive for PAS staining and strongly positive for CK, but negative for CEA, NSE, S-100, actin and vimentin. Moreover, about 50% of the cases were positive for ER and PR. Conclusions Breast GRCC is a rare tumor and has particular histological characteristics. Diagnosis of GRCC depends on histological characteristics and immunohistochemical markers. The biologic characteristics of this tumor need, however, to be further investigated.

关 键 词：乳腺肿瘤 富糖原透明细胞癌 病理学 预后 

分 类 号：R737.9[医药卫生—肿瘤]