116例牙龈癌的治疗与预后分析  

Treatment and Prognosis of Gingival Carcinoma: A Report of 116 Cases

作　　者：郭朱明[1] 王顺兰[1] 张诠[1] 魏茂文[1] 陈文宽[1] 曾宗渊[1] 

机构地区：[1]华南肿瘤学国家重点实验室

出　　处：《癌症》2008年第3期307-310,共4页Chinese Journal of Cancer

摘　　要：背景与目的:牙龈癌是口腔常见的恶性肿瘤,但有关其治疗及预后的文献报道不多。本研究旨在分析影响牙龈癌预后的因素,并探讨合适的治疗方法。方法:选择中山大学肿瘤防治中心1992～2003年住院治疗的初诊牙龈癌患者116例进行回顾性研究。对接受了包括手术治疗、放射治疗以及手术为主的综合治疗的患者进行生存分析。所有患者随访3年以上。结果:100例患者接受根治性治疗,总的3年、5年生存率分别为52.7%、41.8%。单纯手术治疗组与综合治疗组5年生存率分别为50.3%、49.0%,两组生存率差异无统计学意义(P>0.05)。单纯放疗组5年生存率低,仅为20.0%。中晚期患者的复发率综合治疗组明显低于单纯手术治疗组(P<0.05)。多因素分析提示手术切缘状况及分期是影响预后的因素。结论:早期牙龈癌患者适合单纯手术治疗,而中晚期患者主张以手术治疗为主的综合治疗。临床分期及切缘状况影响牙龈癌患者的预后。BACKGROUND ＆ OBJECTIVE： The treatment and prognosis of gingival carcinoma, a common oral carcinoma, have seldom been reported. This study was to explore appropriate therapies and analyze prognostic factors of gingival carcinoma. METHODS： Clinical data of 116 gingival carcinoma patients, treated at Cancer Center of Sun Yat-sen University from 1992 to 2003, were analyzed. Survival analyses were performed for patients who received surgery, radiotherapy, or surgery combined with chemotherapy or/and radiotherapy. The patients had been followed up for more than 3 years. RESULTS： One hundred patients received radical therapy. The overall 3- and 5-year survival rates were 52.7% and 41.8%. The 5-year survival rates were 50.3% in surgery alone group and 49.0% in combined treatment group, without significant difference. The 5- year survival rate of radiotherapy alone group was only 20.0%. For advanced gingival carcinoma, the recurrence rate was much lower in combined treatment group than in surgery alone group. Clinical stage and surgical margin status were predictors of survival. CONCLUSIONS： Surgery alone is appropriate for gingival carcinoma patients at an early stage; surgery combined with chemotherapy or/and radiotherapy is an adequate treatment for patients at advanced stages. Clinical stage and surgical margin status are important prognostic factors.

关 键 词：牙龈肿瘤 综合治疗 预后 

分 类 号：R739.8[医药卫生—肿瘤]