疏血通联合低分子肝素钙治疗频发短暂性脑缺血发作的临床观察  

Clinical study on the curative effect of Shuxuetong injection and low molecular weight heparin on frequent transient ischemic attack

作　　者：李舒曼[1] 李鸿珠[1] 郭津[1] 林岩[1] 徐长庆[1] 

机构地区：[1]哈尔滨医科大学病理生理学教研室,黑龙江哈尔滨150081

出　　处：《哈尔滨医科大学学报》2008年第1期28-30,共3页Journal of Harbin Medical University

基　　金：黑龙江省科技厅国际合作课题(WC02303)

摘　　要：目的观察疏血通注射液联合低分子肝素钙治疗频发短暂性脑缺血发作（TIA）的临床疗效，并初步探讨其血液流变学基础。方法将120例TIA患者随机分成4组（每组30例，10～14天为1疗程）：①对照组（常规阿斯匹林治疗）；②舒血宁组（每日静脉滴注舒血宁注射液20mL）；③疏血通组（每日静脉滴注疏血通注射液6mL）；④联合治疗组（疏血通注射液6mL静脉滴注，同时低分子肝素钙5000单位皮下注射）。结果联合治疗组TIA症状快控率（24h内）优于其它3组，且血液流变学及纤维蛋白原指标有明显改善，而对照组则无明显变化。结论低分子肝素与疏血通联合治疗频发短暂性脑缺血发作是安全有效的，其机制与改善血液流变学指标有关。Objective To observe the curative effect of Shuxuetong injection and low molecular weight heparin on transient ischemic attack （TIA）, and study the related mechanisms. Methods One hundred and twenty TIA patients were randomly divided into 4 groups （ 30 patients for each group） ： （1） control group （ aspirin administration only） ;（2）Shuxuening injection group （Shuxuening injection 20mL by intravenous drip daily） ; （3） Shuxuetong injection group （6 mL of Shuxuetong injection daily） ;（4）combined treatment group（6 mL of Shuxuetong injection and 5 000U of low molecular weight heparin）. Results The symptom rapid control rates of disease in combined treatment group were better than that of other three groups, and the levels of hemorheology and fibrinogen were improved significantly. Conclusion Treatment of TIA to Shuxuetong injection and low molecular heparin is efficient and safe, the mechanism may related to the improvement of hemorheology.

关 键 词：频发短暂性脑缺血发作 低分子肝素钙 疏血通注射液 

分 类 号：R743.31[医药卫生—神经病学与精神病学]