三维CT血管造影在兔症状性脑血管痉挛模型中的应用  

Three dimensional computed tomographic angiography of the vertebral artery in rabbit model of symptomatic cerebral vasospasm

作　　者：周乐平[1] 王均炉[1] 胡章勇[2] 虞慧畅[1] 陈伟健[2] 

机构地区：[1]温州医学院附属第一医院麻醉科,325000 [2]温州医学院附属第一医院影像中心,325000

出　　处：《浙江医学》2008年第1期44-46,共3页Zhejiang Medical Journal

摘　　要：目的评价三维CT血管造影(3D-CTA)在兔症状性蛛网膜下腔出血后迟发性脑血管痉挛(DCVS)模型中的应用价值。方法将双侧颈总动脉结扎2周后存活的兔随机分为实验组(枕大池注血)和对照组(枕大池注0.9%氯化纳注射液),分别在注血前1d(D0)及二次注血后2d(D5)行3D-CTA检查,观察DCVS情况及脑血管等的病理学改变。结果实验组兔基底动脉直径D5平均为D0的69.7%±4.3%,对照组D5平均为D0的98.2%±1.4%,两组的差异有统计学意义(P<0.01),光镜下见基底动脉管壁增厚,内皮细胞脱落。结论3D-CTA是一种可靠、快速和无创的方法,可有效判断脑血管痉挛的程度,为DCVS实验研究提供了一种全新的技术。Objective To establish a model of symptomatic cerebral vasospasm （CVS） following subarachnoid hemorrhage （SAH） in rabbit. To study the three dimensional computed tomographic angiography （3D-CTA）of the basilar artery in rabbit model of symptomatic cerebral vasospasm. Methods After occlusion of bilateral carotid 2 weeks, the survival rabbit were randomized to 2 groups： experimental group （injecting blood twice via cistern ）or control group（ injecting normal saline twice via cistern）. 3D-CTA were used to measure basilar artery diameter on D0 and D5. Results Diameter of the basilar artery was assessed by 3D-CTA, and vasospasm was demonstrated at D5. Diameter of the basilar artery postoperation in the experimental group was smaller than in the control group postoperation （P 〈 0. 01）. Conclusion 3D-CTA is recommended as a reliable, rapid, and minimally invasive diagnostic method, provide a new technique for the delayed cerebral vasospasm research.

关 键 词：症状性脑血管痉挛 兔 三维CT血管造影 

分 类 号：R743[医药卫生—神经病学与精神病学]