鼻内窥镜下鼻腔泪囊造孔术中联合应用5-FU的临床研究  

Clinical effect study of the application of 5-fluorouracil on dacryocystorhinostomy under intranasal endoscopy for chronic dacryocystitis

作　　者：陈祥雷[1] 陶黎明[1] 

机构地区：[1]安徽医科大学第一附属医院眼科,安徽合肥230032

出　　处：《眼外伤职业眼病杂志》2008年第2期114-117,共4页Journal of Injuries and Occupational Diseases of the Eye with Ophthalmic Surgeries

摘　　要：目的 探讨鼻内窥镜下泪囊鼻腔造孔术治疗慢性泪囊炎术中应用5-氟尿嘧啶（5-FU）对预防术后造孔口远期瘢痕粘连的临床效果。方法 42例48眼慢性泪囊炎随机分两组。在施行鼻内窥镜下泪囊鼻腔造孔手术中冷光源的引导下联合应用5-氟尿嘧啶置于造孔口骨窗处（治疗组）21例25眼；及单纯行鼻内窥镜下泪囊鼻腔造孔术（对照组）21例（23眼）。共治疗42例（48眼）慢性泪囊炎，随访3～12个月。结果 治疗组3～6个月，6～12个月治愈率分别为96．00％、92．00％，对照组3～6个月、6～12个月治愈率分别为78．26％、69．56％。经χ^2检验治疗组治愈率高于对照组（P〈0．05）。结论 鼻内窥镜下泪囊鼻腔造孔术联合术中联合应用5-FU有利于提高术后远期疗效，是一种创伤小，安全有效的新方法。Objective To study long-term clinical curative effect of the application of 5-FU on postoperative lacrimal passages cicatricial adhesion after dacryocystorhinostomy under intranasal endoscopy for chronic dacryocystitis. Methods The forty-two patients（48 eyes） are random selected two groups：one group（21 cases） of the patients after dacryocystorhinostomy under intranasal endoscopy for chronic dacryocystitis are applied to place 5-FU on thebone window guiding cold light （ Treat Group）. another group （ 21 cases） patients merely carried out dacryocystorhinostomy under intranasal endoscopy（ Control Group）. All of them were followed up 3 to 12 months. Results 96.00% of Treat Group（21 cases;25 eyes） are recovered following up 3 to 6 months and 92.00% of Treat group are recovered following up 6 to 12 months, but 78.26% of Control Group（21 cases;23 eyes） are recovered following up 3 to 6 months and 69.56% of Control Group are recovered following up 6 to 12 months. The recovery rate of Treat Group exceeds Control Group fromx2 test. Conclusions The once application of 5-FU on postoperative lacrimal passages cicatricial adhesion after dacryocystorhinostomy under endoscopy treating chronic dacryocystitis profits to prostecdtive efficacy. It＇ t a tiny wound and nwe safe effective method.

关 键 词：内窥镜 5-氟尿嘧啶 泪囊炎 治疗 

分 类 号：R779.6[医药卫生—眼科]