萎缩性胃炎伴隆起糜烂与环氧合酶-2、c-met癌基因蛋白的关系  

Expression of cyclooxygenase-2 and c-met proteins in atrophic gastritis with convex erosion

作　　者：冯莉[1] 谢蕴[1] 吴云林[1] 

机构地区：[1]上海瑞金医院集团闵行区中心医院消化科,上海201100

出　　处：《上海医学》2007年第12期917-919,共3页Shanghai Medical Journal

基　　金：上海市科学技术委员会科研基金(044119741)

摘　　要：目的观察萎缩性胃炎伴隆起糜烂组织环氧合酶(COX)-2、c-met癌基因蛋白的表达情况,探讨其与胃癌发生的关系。方法对萎缩性胃炎伴隆起糜烂、非萎缩性胃炎及胃癌各50例患者的胃镜活检组织进行免疫组织化学检查,比较COX-2、c-met癌基因蛋白的表达情况。结果3组间c-met表达阳性率的差异有统计学意义(P=0.012),萎缩性胃炎伴隆起糜烂组显著高于非萎缩性胃炎组(P=0.050),但与胃癌组的差异无统计学意义(P=0.260)。3组间COX-2表达阳性率的差异有统计学意义(P=0.018),萎缩性胃炎伴隆起糜烂组显著高于非萎缩性胃炎组(P=0.006),但与胃癌组的差异无统计学意义(P=0.817)。结论COX-2、c-met癌基因蛋白在萎缩性胃炎伴隆起糜烂组织均存在高表达,提示萎缩性胃炎伴隆起糜烂胃黏膜病变细胞处在高度增殖状态,并具有恶化倾向。Objective To study the expressions of cyclooxygenase（COX）-2 and c-met proteins in the tissue of atrophic gastritis with convex erosion. Methods The expressions of COX-2 and c-met proteins were detected with immunohistochemistry in 50 specimens of atrophic gastritis with convex erosion, 50 chronic superficial gastritis and 50 gastric carcinoma tissues. Results c-met protein expression was significantly higher in the atrophic gastritis tissue than in superficial gastritis tissue （P = 0. 050）, but similar between the atrophic gastritis and carcinoma tissues （P = 0. 260）. COX-2 expression was also significantly higher in the atrophic gastritis than in the superficial gastritis tissues （P = 0. 006）, and comparable between the atrophic gastritis and gastric carcinoma tissues （P = 0. 817）. Conclusion High expressions of COX-2 and c-met proteins are present in atrophic gastritis with convex erosion, suggesting highly active proliferation of the cells in the involved gastric mucosa, which may give rise to carcinogenesis. （Shanghai Med J, 2007, 30 ： 917-919）

关 键 词：萎缩性胃炎伴隆起糜烂 环氧合酶-2 C-MET 

分 类 号：R573.3[医药卫生—消化系统]