乳腺癌组织中COX-2、bFGF的表达与临床病理参数的关系  

Relation between the expression of COX-2, bFGF and the clinical pathologic parameter in breast cancer

作　　者：朱国民[1] 钟德玝[1] 吴唯[2] 易文君[1] 孙萍[1] 

机构地区：[1]中南大学湘雅二医院普外科,湖南长沙410011 [2]中南大学湘雅三医院普外科,湖南长沙410013

出　　处：《中国医学工程》2007年第10期803-805,808,共4页China Medical Engineering

摘　　要：目的探讨环氧化酶-2(Cyclooxygenase-2,COX-2)和碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)在乳腺癌组织中的表达及其临床意义。方法采用免疫组织化学S-P法检测60例乳腺癌组织中COX-2和bFGF的表达。结果在恶性肿瘤国际临床病期分类(TNM)Ⅰ～Ⅱ乳腺癌组织中COX-2的阳性系数均数为(1.03±1.28),bFGF的阳性系数均数为(1.08±1.21),在TNMⅢ～Ⅳ乳腺癌组织中COX-2的阳性系数均数为(3.09±1.70);bFGF的阳性系数均数为(3.00±1.91)。TNMⅢ～Ⅳ乳腺癌组织中COX-2和bFGF的表达明显高于TNMⅠ～Ⅱ(P<0.01)。在淋巴结阳性组乳腺癌组织中COX-2的阳性系数均数为(2.76±1.66),bFGF的阳性系数均数为(2.82±1.57);在淋巴结阴性组乳腺癌组织中COX-2的阳性系数均数为(0.67±1.07),bFGF的阳性系数均数为(0.59±1.12)。淋巴结阳性组乳腺癌组织中COX-2和bFGF的表达明显高于淋巴结阴性组(P<0.01)。结论COX-2、bFGF高表达可能与乳腺癌的预后有关。[Objective] To study the significance of the expression of COX-2 and bFGF in breast cancer. [Methods] Immunohistochemical method （S-P） was used to study the expression of COX-2 and bFGF in 60 breast cancer tissues. [Results] The expressions of COX-2 and bFGF in TNMⅠ - Ⅱ breast cancer were （1.03±1.28）, （1.08±1.21）, but those in the TNMⅢ-Ⅳ were （3.09±1.70） and （3.00±1.91）. The expressions of COX-2 and bFGF in TNMⅢ-Ⅳ breast cancer were higher than those in the TNMⅠ - Ⅱ （P 〈0.01）. The expressions of COX-2 and bFGF in the breast cancer with lymph node metastasis were （2.76±1.66） and （2.82±1.57）, but those in the breast cancer without lymph node metastasis were （0.67±1.07）, （0.59±1.12）. The expressions of COX-2 and bFGF in the breast cancer with lymph node metastasis were higher than those in the breast cancer without lymph node metastasis （P 〈 0.01）. [Conclusion] The overexpression of COX-2 and bFGF in breast cancer might be related to the prognosis of breast cancer.

关 键 词：乳腺肿瘤 环氧化酶-2 碱性成纤维细胞生长因子 

分 类 号：R737.9[医药卫生—肿瘤]