乳腺癌易感基因BRCA1、BRCA2在浸润性导管癌中的表达及意义  

Expression of BRCA1 and BRCA2 gene protein in breast invasive ductal carcinoma and its significance

作　　者：刘德纯[1] 赵云霞[2] 承泽农[1] 

机构地区：[1]蚌埠医学院第一附属医院病理科,安徽省蚌埠233003 [2]蚌埠医学院病理生理学教研室

出　　处：《中国基层医药》2008年第1期55-57,共3页Chinese Journal of Primary Medicine and Pharmacy

基　　金：安徽省教育厅自然科学研究计划项目（2004kj277）

摘　　要：目的探讨乳腺癌易感基因BRCA1、BRCA2蛋白的异常表达在乳腺浸润性导管癌发生、发展中的作用及其意义。方法应用免疫组织化学S-P法检测BRCA1、BRCA2蛋白在121例乳腺浸润性导管癌标本和30例乳腺良性增生性病变中的表达；并将检测结果与临床病理指标的关系进行相关性分析。结果BRCA1、BRCA2基因蛋白在乳腺癌组与乳腺良性病变组中的异常表达差异有统计学意义，其失表达率随乳腺癌组织学分级的增高而增高，在低年龄组、雌激素受体（ER）阴性组BRCA1基因蛋白失表达率增高，BRCA1和BRCA2在乳腺癌中的失表达具有一致性。结论BRCA1、BRCA2蛋白在乳腺良性病变中有很高的表达，在乳腺癌中其表达率下降，且均与乳腺癌组织学分级具有不同程度的关系，表明其肿瘤抑制功能丧失，促进细胞的肿瘤性转化，对遗传性和散发性乳腺瘤的发生发展具有相似的作用。Objective To explore the role of aberrant expression of BRCA1 and BRCA2 in the happening and development of breast invasive ductal carcinoma （IDC） and its significance.Methods Immunohistochimical technique （S-P method）was used for detecting the expresslons of BRCA1 and BRCA2 proteins in 121 cases of breast IDC,and 30 cases of benign proliferative lesions.The results were analyzed together with some clinical pathological parameters.Results The expressions of BRCA1 and BRCA2 proteins didn＇t show statistical difference between breast cancer and benign lesions.The protein negative rate of BRCA1 and BRCA2 rose with histological grade,and higher in younger patients （〈50 years old ）and the patients with ER negative expression.Expreesions of BRCA1 and BRCA2 proteins were unanimous in breast concer with or without family medical history.Conclusion Expressive rate of BRCA1,BRCA2 proteins are higher in benign lesions.The expressions decrease in breast IDC and have a certain relationship with hisgological grade,age,and ER expression.The loss of function of inhibiting tumor induce neoplastio transformation.It indicates that they react to the development of both hereditary and diverging breast cancer.

关 键 词：乳腺肿瘤BRCA1蛋白质 BRCA2蛋白质 病理学 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]