生化法检测组织蛋白酶-D在淋巴结阴性乳腺癌中的预后作用  

CATHEPSIN D AS A PROGNOSTIC INDICATOR FOR NODE NEGATIVE BREAST CANCER PATIENTS USING BIOCHEMICAL ASSAY

作　　者：邵志敏[1] 江明[1] 沈镇宙[1] 

机构地区：[1]上海医科大学附属肿瘤医院外科

出　　处：《中国癌症杂志》1997年第2期97-100,共4页China Oncology

摘　　要：研究淋巴结阴性乳腺癌标本中组织蛋白酶－Ｄ（ｃａｔｈｅｐｓｉｎ－Ｄ）的含量及其预后价值。方法应用生化法检测１９８例乳腺癌标本中组织蛋白酶－Ｄ的含量，结合统计学生存率分析和单个相互因素分析方法，研究其在患者预后中的作用。结果（１）１９８例乳腺癌标本中，１６２例淋巴结阴性，３６例淋巴结阳性，淋巴结阳性标本中组织蛋白酶－Ｄ的含量要高于淋巴结阴性者。（２）１６２例淋巴结阴性患者中组织蛋白酶－Ｄ低表达患者的总生存率和无病生存率要高于中、高表达者。（３）组织蛋白酶－Ｄ的含量高低是唯一能对乳腺癌总生存率和无病生存率有提示作用的预后指标。结论应用生化法检测淋巴结阴性乳腺癌标本中组织蛋白酶－Ｄ的含量是临床判断患者预后的重要指标。PURPOSE To study the cathepsin D level in node negative breast cancer sample and its prognostic value. METHODS This is a retrospective study on 198 breast cancer patients, with both biochemical and clinical factors being measured for determination of prognostic markers. RESULTS 1.162 patients were node negative, and 36 patients were node positive. The cathepsin D levels were much higher in node positive cases than that in node negative patients. 2.In 162 node negative patients, high levels of cathepsin D predicted poor relapse free and overall survival. 3.The cathepsin D values were useful as predictors of outcome after multivariate analysis. CONCLUSIONS Cathepsin D level detected by biochemical assay is the most useful prognostic indicator in node negative breast cancer patients.

关 键 词：组织蛋白酶 恶性肿瘤 预后 乳腺癌 生化法 检测 

分 类 号：R737.9[医药卫生—肿瘤]