盐酸西布曲明对高脂肥胖大鼠下丘脑增食欲素系统的影响  

The effect of sibutramine hydrochloride on expression of hypothalamus orexin system gene in high-fat dietary obesity rats

作　　者：陈洲[1] 廖丽萍[2] 刘礼斌[2] 

机构地区：[1]福建医科大学药学院,福建福州350001 [2]福建医科大学附属协和医院福建省内分泌研究所,福建福州350001

出　　处：《中国药理学通报》2008年第2期262-265,共4页Chinese Pharmacological Bulletin

基　　金：福建省教育厅资助项目(NoK2001082)

摘　　要：目的观察盐酸西布曲明对高脂饮食肥胖大鼠下丘脑增食欲素系统基因表达的变化。方法建立高脂饮食肥胖大鼠模型,分组连续灌胃给药4wk,观察盐酸西布曲明给药对高脂饮食肥胖大鼠体重、血脂、血糖及下丘脑前增食欲素原及增食欲素受体mRNA表达的影响。结果盐酸西布曲明8mg·kg-1能明显降低高脂肥胖大鼠体重、血糖和血脂;升高肥胖大鼠下丘脑前增食欲素原mRNA表达水平;各组间增食欲素受体1和2mRNA表达无变化。结论盐酸西布曲明具有减重、降脂和增加高脂饮食肥胖大鼠下丘脑前增食欲素原基因表达的作用。Aim hydrochloride on To study the effect of sibutramine hypothalamus orexin system gene in high-fat dietary obesity rats. Methods SD rats were fed with high-fat diet to induce obesity model. Then, the rats were divided into two groups , the treatment group with sibutramine （8 mg· kg^-1, ig） and control group with NaCI（ig） for 4 weeks. All rats＇ weight, blood fat and glucose were measured, prepro-orexin and its receptors mRNA expression in the hypothalam assessed by semi-quantity RT-PCR. Results US were Sibutra-mine not only decreased the obesity rats＇ weight and the level of serum lipid and glucose, but also increased the level of prepro-orexin mRNA expression in obesity rats. There was no difference in mRNA expression of both orexin receptors in each group. Conclusions Sibutramine hydrochlorid has an anti-obesity effect in high-fat obesity rats, which may be related to the increase of prepro-orexin gene mRNA expression level.

关 键 词：盐酸西布曲明 肥胖 增食欲素 基因表达 

分 类 号：R-332[医药卫生] R342.22