TGF—β信号通路在肿瘤发生、发展和转移中的作用  

TGF-β Signaling Pathway's Function in Tumor Initiation, Progression and Metastasis

作　　者：王天昱[1] 范宇[1] 李丹[1] 王玺[1] 吴静云[1] 栾丽菊[2] 秦丽华[2] 

机构地区：[1]北京大学医学部基础医学院,北京100083 [2]北京大学医学部解剖学与组织胚胎学系,北京100083

出　　处：《解剖科学进展》2008年第1期87-91,共5页Progress of Anatomical Sciences

基　　金：国家基础科学培养基金资助(No.J0630853/J0108)

摘　　要：转化生长因子β(transforming growth factors-β,TGF-β)是一类具有多种生物学活性的细胞因子,参与调节细胞的增殖、分化、发育和凋亡等多种生命活动。TGF-β对肿瘤的作用是极其复杂的。在空间方面,TGF-β信号通路对肿瘤细胞自身的作用在肿瘤抑制和肿瘤发展机制中有重要意义,又能通过影响肿瘤的微环境(如成纤维细胞、免疫细胞和细胞外基质)来促进或抑制肿瘤的发展和转移;在时相方面,TGF-β在肿瘤早期可抑制细胞增殖、启动细胞分化并诱导凋亡,但在肿瘤的进展期则可通过多种机制促进肿瘤的侵袭和转移。TGF-β信号通路的复杂特性对肿瘤机制的研究和肿瘤的靶向治疗提供了全新的机遇和挑战。Transforming growth factors- β （TGF- β ） are a class of cytokines with many kinds of biologic activity, which regulate cell proliferation, differentiation, development and apoptosis. According to the studies in recent years, TGF- β acts upon tumor through a broad and complex spectrum of interdependent interactions. In terms of sites, TGF- β signaling pathways show a significant role in tumor suppression and tumor promotion by tumor-cell-autonomous effects, and also promote or suppress carcinoma progression and metastasis by affecting the tumor microenvironment, such as fibroblasts, immune cells and the extracellular matrix. In terms of stages, prior to initiation and early during progression TGF- β acts as a tumor suppressor restraining cell proliferation, initiating cell differentiation and inducing cell apoptosis, however at later stages in tumor progression it often acts in many ways to promote tumor migration and metastasis. The complex nature of TGF-β signaling presents a unique challenge and an opportunity to discover the mechanism of tumor and to develop therapeutic intervention strategies for targeting cancer.

关 键 词：侵袭和转移 肿瘤发生 信号通路 TGF 抑制细胞增殖 转化生长因子 诱导凋亡 细胞分化 

分 类 号：R739.8[医药卫生—肿瘤] R730.231[医药卫生—临床医学]