胸腺细胞分化发育的凋亡调控  

Regulation of Apoptosis in the Differentiation and Development of Thymocytes

作　　者：郑琳[1] 周瑞祥[1] 

机构地区：[1]福建医科大学 人体解剖与组织胚胎学系,福建福州350004

出　　处：《解剖科学进展》2008年第1期105-110,共6页Progress of Anatomical Sciences

基　　金：福建省教育厅重大项目(2005K043);福建医科大学教授基金(js07002)

摘　　要：胸腺细胞在胸腺内的发育过程经历了TCR基因重排与表达、阳性选择和阴性选择三个主要过程。凋亡,又称程序性细胞死亡,在胸腺细胞发育过程贯穿始终,因此研究胸腺内T细胞发育过程中的凋亡对揭示胸腺选择作用和中枢耐受形成机制有重要意义。本文就胸腺细胞在胸腺内发育过程中凋亡的发生及其调控作一综述。During the development and maturation of thymocytes, three main events play a critical role in shaping the T cell repertoire, including the rearrangement and expression of TCR β and TCR α locuses, positive selection and negative selection. Apoptosis, or programmed cell death, is the very way to deleting unproductive and potentially autoreactive T cells. Therefore, to investigate selective apoptosis in thymus is meaningful for enlarging our knowledge of the mechanism of thymocytes elimination and central tolerance.

关 键 词：凋亡调控 胸腺内 细胞分化发育 TCR基因重排 程序性细胞死亡 发育过程 胸腺细胞 阴性选择 

分 类 号：R734.2[医药卫生—肿瘤] R657.3[医药卫生—临床医学]