新型人工髓核材料--果胶／聚乙烯醇复合水凝胶的制备及其溶胀性能  

Preparation and swelling properties of pectin/poly(vinyl alcohol) composite hydrogel for prosthetic nucleus pulposus

作　　者：黄曹[1] 卢玲[2] 瞿东滨[1] 张忠民[1] 金大地[1] 

机构地区：[1]南方医科大学南方医院脊柱骨病外科,广州510515 [2]南方医科大学药学院化学系,广州510515

出　　处：《复合材料学报》2008年第1期69-74,共6页Acta Materiae Compositae Sinica

摘　　要：利用低频振荡、冻融法制得果胶／聚乙烯醇复合（CoPP）水凝胶，采用红外光谱仪、差示扫描量热仪、X射线衍射仪、扫描电镜，表征其结构；观察CoPP水凝胶的溶胀性能，并探讨扩散模式及溶胀动力学。结果表明：CoPP水凝胶是一种多孔材料、有两个结晶区，脱水后可再次水合、溶胀；水分子以菲克扩散模式渗入CoPP水凝胶，CoPP水凝胶的溶胀速率常数、溶胀平衡时的质量溶胀率（197．38％～252．49％）、体积溶胀率（241．47％～308．93％），均大于聚乙烯醇（PVA）水凝胶。因此，CoPP水凝胶具有溶胀快和溶胀率大等特点，可减小人工髓核假体植入时的尺寸，利于微创手术植入。The pectin/poly （vinyl alcohol） composite （CoPP） hydrogel was prepared by low frequency oscillation and freezing-thawing. The structure of CoPP hydrogel was characterized by FTIR, DSC, XRD and SEM, the swelling properties were observed, and the diffusion of water and the swelling dynamics were also discussed. The experi- mental results show that CoPP hydrogel is porous, and has two kinds of crystal regions. The diffusion characteristic index which water molecule immerses into CoPP hydrogel was near 0. 5, which indicates the diffusion is in Fick model. The swelling velocity constant of CoPP, the swelling ratio of mass （197.38% ～252.49%） and swelling ratio of volume （241.47% ～ 308.93 % ） of CoPP at the swelling equilibration were superior to those of poly （vinyl alcohol） （PVA） hydrogel. Therefore, the swelling properties of CoPP composite hydrogel are faster and larger, which makes it possible to implant the artificial nucleus pulposus prosthesis in smaller size with the minimally invasive surgery.

关 键 词：水凝胶 溶胀 果胶 聚乙烯醇 人工髓核 

分 类 号：R318.08[医药卫生—生物医学工程] R681.5[医药卫生—基础医学]