络合Ca^2＋对山羊膀胱经经穴氧分压的影响  

Effect of Ca^(2+) Complexation on Oxygen Partial Pressure in the Bladder Meridian in Goats

作　　者：王琪[1] 蒋红芝[1] 陈胜利[2] 张明敏[3] 丁明星[4] 孔鄂生[5] 黄光英[1] 

机构地区：[1]华中科技大学附属同济医院中西医结合研究所,武汉430030 [2]华中科技大学同济医学院药物分析学系,武汉430030 [3]华中科技大学附属同济医院中西医结合科,武汉430030 [4]华中农业大学畜牧兽医学院,武汉430070 [5]华中科技大学同济医学院环境医学研究所,武汉430030

出　　处：《针刺研究》2008年第1期17-21,共5页Acupuncture Research

基　　金：国家自然科学基金资助重点项目(No.90209009)

摘　　要：目的:探讨Ca2+和组织氧分压与经络现象之间的联系。方法:波尔杂交母山羊10只,用盐酸氯丙嗪(0.85 mg/kg)镇静后,采用乙二胺四乙酸二钠(EDTA-Na2200μL,0.05 kg/mol)络合穴区局部组织Ca2+,用新型组织氧分压传感针检测山羊膀胱经经穴"肝俞""大肠俞""关元俞"及旁开非经穴处氧分压的变化趋势。结果:1)膀胱经经穴的Ca2+电位明显高于旁开对照点(P<0.05,0.01);2)膀胱经经穴的组织氧分压高于旁开对照点(P<0.01);3)注射EDTA-Na2后,经穴的氧分压较注射前及注射生理盐水均明显升高(P<0.01),且经穴的氧分压高于旁开对照点(P<0.01)。结论:膀胱经穴Ca2+电位明显高于各自旁开对照点;注射EDTA-Na2络合Ca2+后氧分压明显升高。Objective To explore the relationship between energy metabolism and meridian phenomenon. Methods Ten Boer hybridism goats mitigated under chlorpromazine （0.85 mg/kg, intramuscular injection） were subjected to the present study. Changes of oxygen partial pressure （PO2） in ＂Ganshu＂ （BL 18）, ＂Dachangshu＂ （BL 25） and ＂Guanyuanshu＂ （BL 26） of Bladder Meridian and in 3 non-acupoints （3 cm apart from BL18, BL25 and BL26 separately on the unilateral side） were recorded by using a needle-type tissue oxygen tension sensor before and following local injection of EDTA-Na2 （200 μL, 0.05 kg/mol, for complexing Ca^2＋ ） and 0.9% saline. Results （1） Compared with the corresponding non-acupoints, Ca^2＋ potentials in BL18, BL25 and BL26 were all significantly higher （P〈0.05, 0.01 ）. （2） In comparison with the corresponding non-acupoints, the values of tissue PO2 of BL18 and BL26 were significantly higher （P〈0.01）. （3） After injection of EDTA-Na2, PO2 values in both BL18, BL26, and their respective non-acupoints increased significantly in comparison with those of either injection of saline or their respective basal values （P〈0.01,0.05）. Compared with those of their corresponding non-acupoints PO2 values in both BL18 and BL26 increased markedly （P〈0.01）. Conclusion Ca^2＋ potential of the Bladder Meridian was significantly higher than that of non-acupoints, and after complexing Ca^2＋ , PO2 in acupoints and non-acupoints increased markedly, suggesting that Ca^2＋ may play an important role in meridian signaling and production of acupuncture effect.

关 键 词：氧分压 CA^2+ 膀胱经 

分 类 号：R224.1[医药卫生—中医基础理论]