老年人非酮症高血糖性舞蹈病的临床和颅脑影像学特点（附三例报告）  

Clinical and imaging features of chorea associated with non-ketotic hyperglycemia in elderly patients

作　　者：曹丽丽[1] 郭斌[1] 陈瑞冬[1] 郭春妮[1] 李红梅[1] 

机构地区：[1]山东大学齐鲁医院神经内科,济南市250012

出　　处：《中华老年医学杂志》2008年第2期91-94,共4页Chinese Journal of Geriatrics

摘　　要：目的观察非酮症高血糖性舞蹈病患者的临床和颅脑MRI变化的特点，为本病的早期诊断和正确治疗提供帮助。方法对3例急性发病的老年非酮症高血糖舞蹈病患者，动态观察其临床、实验室检查和影像学变化，并给予控制血糖和抗舞蹈病药物治疗。结果患者发病时血糖和血浆渗透压升高，舞蹈症状的严重程度与血糖呈正相关，急性期颅脑MRI T1相上呈基底节区高信号，随着症状的缓解，上述信号消失。结论非酮症性高血糖舞蹈病是一特殊的综合征，有着特异性的影像学表现，呈良性经过，预后良好。Objective To investigate the clinical and brain magnetic resonance imaging features of chorea associated with non-ketotic hyperglycemia in the elderly. Methods Three patients with chorea associated with non-ketotic hyperglycemia were enrolled in the study. The clinical changes, blood glucose level and magnetic resonance imaging findings were observed dynamically. Results The patients had an elevated serum glucose level and higher osmotic pressure on admission, and the symptoms were controlled by antidiabetic drug and dopamine receptor blockings. The chorea improved with the blood sugar level decreasing. The Tl-weighted brain magnetic resonance images showed high signal intensity of basal ganglia lesions in acute phase, which disappeared with the improvement of chorea. Conclusions Chorea associated with non-ketotic hyperglycemia is a benign disorder affecting the elderly. The high signal intensity of basal ganglia lesion on the Tl-weighted brain MRI study is reversible, and correlated with the clinical improvement in chorea.

关 键 词：舞蹈症性障碍 高血糖症 糖尿病 2型 脑 磁共振成像 

分 类 号：R742.2[医药卫生—神经病学与精神病学]